Sonal Dubey

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HIV-1 integrase (IN) is an essential enzyme for retroviral replication. It is involved in the integration of HIV DNA into host chromosomal DNA. The unique properties of IN makes it an ideal target for drug design. First, there appears to have no functional equivalent in human cells and the reactions catalyzed by IN are unique. Second, IN is absolutely(More)
Cloud computing systems promise to offer pay per use, on demand computing services to users worldwide. Recently, there has been a dramatic increase in the demand for delivering services to a large number of users, so they need to offer differentiated services to users and meet their expected quality requirements. Most of scheduling schemes proceeding(More)
Ocimum is a genus of aromatic herbs, undershurbs or shrubs distributed in the tropical and warm temperate regions of the world. Larvicidal activity of essential oils and different extracts of O. sanctum, O. basilicum and O. gratissimum were compared on laboratory reared and field collected larvae of Culex quinquefasciatus. Thin layer chromatographic(More)
The aim of artificial intelligence is to develop tools for representing piece of knowledge and providing inference mechanism for elaborating conclusion of knowledge from stored information. The available knowledge is far from being certain, precise and complete. In Expert systems the word uncertainty is related to the working with inexact data, imprecise(More)
In a systematic effort aimed at identifying new steroidal cytotoxic agents with potent antipoliferative activity against cancer cells and developing their QSAR models, series of 4-nitro, 4-isopropyl, 4-methoxy and 3,4-dimethoxy substituted benzylidene androst-5-ene derivatives were synthesized. The selected compounds were evaluated for antineoplastic(More)
The title compound, C(25)H(31)NO(2).H(2)O, has the outer two six-membered rings in chair conformations, while the central ring is in an 8beta,9alpha-half-chair conformation. The five-membered ring adopts a 13,14-half-chair conformation. The pyridylmethylene moiety has an E configuration with respect to the carbonyl group at position 17. The structure is(More)
The title compound, C(32)H(45)N(2)O(+).Br(-).0.5H(2)O, has the outer two six-membered rings in chair conformations, while the central ring is in an 8beta,9alpha-half-chair conformation. The five-membered ring of the steroid nucleus adopts a slightly deformed 14alpha-envelope conformation. The pyridylmethylene moiety has an E configuration with respect to(More)
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large number of research articles and patents described them, and several drugs based on its nucleus have come into light. Pyridazinone, a derivative of pyridazine, was initially exploited in search of cardiovascular drugs and for its(More)
The recent interests in the development of novel and potent bifunctional quinolonyl diketo acid derivatives as integrase inhibitors for the treatment of HIV-1 infection-inhibiting 3′ processing and strand transfer in the virus have been explored using classical Quantitative Structure Activity Relationship (QSAR) tools in an attempt to delve into the(More)