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A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12
The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastaticExpand
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  • Open Access
A Transcript Cleavage Factor of Mycobacterium tuberculosis Important for Its Survival
After initiation of transcription, a number of proteins participate during elongation and termination modifying the properties of the RNA polymerase (RNAP). Gre factors are one such group conservedExpand
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  • Open Access
Inhibition of Mycobacterium tuberculosis RNA polymerase by binding of a Gre factor homolog to the secondary channel.
Because of its essential nature, each step of transcription, viz., initiation, elongation, and termination, is subjected to elaborate regulation. A number of transcription factors modulate the ratesExpand
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Mycobacterium tuberculosis Cyclophilin A Uses Novel Signal Sequence for Secretion and Mimics Eukaryotic Cyclophilins for Interaction with Host Protein Repertoire
Cyclophilins are prolyl isomerases with multitude of functions in different cellular processes and pathological conditions. Cyclophilin A (PpiA) of Mycobacterium tuberculosis is secreted duringExpand
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Microbial Community Response to Simulated Petroleum Seepage in Caspian Sea Sediments
Anaerobic microbial hydrocarbon degradation is a major biogeochemical process at marine seeps. Here we studied the response of the microbial community to petroleum seepage simulated for 190 days in aExpand
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  • Open Access
The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases
How cells in primary tumors initially become pro-metastatic is not understood. A previous genome-wide RNAi screen uncovered colon cancer metastatic suppressor and WNT promoting functions of TMED3, aExpand
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  • Open Access
Hydrocarbon Degradation in Caspian Sea Sediment Cores Subjected to Simulated Petroleum Seepage in a Newly Designed Sediment-Oil-Flow-Through System
The microbial community response to petroleum seepage was investigated in a whole round sediment core (16 cm length) collected nearby natural hydrocarbon seepage structures in the Caspian Sea, usingExpand
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Biodegradation of petroleum in marine seep sediments
This study presented for the first time the use of intact sediment cores in a continuous sediment-oil-flow-through (SOFT) system for investigating the degradation of petroleum under a simulatedExpand
Functional dissection of TMED proteins in colon cancer metastasis
Les metastases du cancer du colon sont la cause majeure de deces dus a cette maladie. Les etudes de sequencage genomique destinees a trouver des mutations pilotes pour la progression metastatiqueExpand
Inhibition of Mycobacterium tuberculosis RNA polymerase by 1 binding of a Gre factor homolog to secondary channel 2 3 4
4 Arnab China, Sonakshi Mishra, Priyanka Tare and Valakunja Nagaraja 2, * 5 6 7 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 8 560012, India 9 Jawaharlal NehruExpand