Somnath Tagore

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Toxicogenomics is defined as an integration of genomics (transcriptomics, proteomics and metabolomics) and toxicology. It is a scientific field that studies how the genome is involved in responses to environmental stressors and toxicants. It combines studies of mRNA expression, cell and tissue-wide protein expression and metabonomics to understand the role(More)
Merozoites are the surface antigens and variant antigens expressed on the surface of malaria-infected erythrocytes (including PfEMP1) are both targets of protective antibody responses. The mechanism of the modified immune response was observed after subpatent infections. Subpatently infected mice had increased antigen-specific T-cell responses; they were(More)
RNAi (RNA interference) refers to the introduction of homologous double stranded RNA (dsRNA) to specifically target a gene's product, resulting in null or hypomorphic phenotypes. Long double-stranded RNAs (dsRNAs; typically >200 nt) can be used to silence the expression of target genes in a variety of organisms and cell types (e.g., worms, fruit flies, and(More)
Microarrays are a powerful tool has multiple applications both in clinical and cellular and molecular biology arenas. Early assessment of the probable biological importance of drug targets, pharmacogenomics, toxicogenomics and single nucleotide polymorphisms (SNPs). A list of new drug candidates along with proposed targets for intervention is described.(More)
Pathway analysis is one of the most interesting aspects of Systems Biology. Modeling biological pathways is interesting as well as difficult to optimize. Various modeling problems of diseases can be successfully analyzed using this simulation approach. Graphical probabilistic approaches are one of the unique methodologies that are used for designing and(More)
Discovery of chimeric RNAs, which are produced by chromosomal translocations as well as the joining of exons from different genes by trans-splicing, has added a new level of complexity to our study and understanding of the transcriptome. The enhanced ChiTaRS-3.1 database ( is designed to make widely accessible a wealth of mined(More)
Proteomics technologies have produced an abundance of drug targets, which is creating a bottleneck in drug development process. There is an increasing need for better target validation for new drug development and proteomic technologies are contributing to it. Identifying a potential protein drug target within a cell is a major challenge in modern drug(More)
BACKGROUND A complex network of biochemical reactions present in an organism generates various biological moieties necessary for its survival. It is seen that biological systems are robust to genetic and environmental changes at all levels of organization. Functions of various organisms are sustained against mutational changes by using alternative pathways.(More)
Kinomics is derived from the word kinome that is the kinase part of the proteome. Kinomics is a merger between genomics and proteomics. Defining the kinase complement of the human genome, the kinome, has provided an excellent starting point for understanding the scale of the problem. This approach combines the understanding of small molecules and targets,(More)
Metabolomics is one of the key approaches of systems biology that consists of studying biochemical networks having a set of metabolites, enzymes, reactions and their interactions. As biological networks are very complex in nature, proper techniques and models need to be chosen for their better understanding and interpretation. One of the useful strategies(More)