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Evaluation of the topical spray containing Centella asiatica extract and its efficacy on excision wounds in rats
TLDR
An in vivo excision wound healing model showed that wound excision was completely healed after 14 days and the skin irritation study indicated that the formulation was non-irritating in a rat model. Expand
Enhanced dissolution of sildenafil citrate as dry foam tablets
TLDR
Dry foam formulation technology is alternative approach to enhance dissolution of the drug sildenafil citrate with the high- level composition of surfactant, water and diluent showed enhanced dissolution rate than that of the lower-level composition of these excipients. Expand
Sildenafil citrate monohydrate-cyclodextrin nanosuspension complexes for use in metered-dose inhalers.
TLDR
Only sildenafil citrate monohydrate pMDI formulations containing CDs were suitable for use as aerosols, because the formulations without CDs produced a low emitted dose of sildanafil (<60%). Expand
Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability
TLDR
It is concluded that the SMEDDS chewable formulation can be used to improve the dissolution and systemic availability of poorly water-soluble drugs. Expand
Analytical Validation of Sildenafil Citrate Inhaler Preparation
TLDR
A reversed phase HPLC system for the separation and quantitation of sildenafil citrate assay was successfully developed and validated and was able to resolve any degradation products from the sildanafil peak. Expand
Evaluation of sildenafil pressurized metered dose inhalers as a vasodilator in umbilical blood vessels of chicken egg embryos.
TLDR
Sildenafil citrate pressurized metered dose inhalers (pMDI) used ethanol as a solvent, PEG400 as a stabilizing agent, sorbitan monooleate as a surfactant and HFA-134a as a propellant to investigate the efficacy in relieving a vasoconstricted umbilical blood vessel of the chicken egg embryo. Expand
PREPARATION OF ISONIAZID AS DRY POWDER FORMULATIONS FOR INHALATION BY PHYSICAL MIXING AND SPRAY DRYING
The main purpose of this study is to develop isoniazid as dry powder aerosol for delivery to the lower airways and to study the susceptibility of M. bovis and M. tuberculosis to the formulationsExpand
METHOD VALIDATION FOR DETERMINATION OF SILDENAFIL CITRATE IN EXTEMPORANEOUS ORAL SUSPENSION
Objective: The aim of this study was to validate a high-performance liquid chromatographic (HPLC) method for analysis of sildenafil citrate in an extemporaneous preparation, according to ASEANExpand
Why sildenafil and sildenafil citrate monohydrate crystals are not stable?
TLDR
Notably, the obtained crystals of sildenafil free base and salt forms were different from their different growing conditions leading to stability difference, and were perfected if the process was an acidic pH at a cold temperature then perfect crystals occurred within a day. Expand
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