Somayeh Zargooshnia

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Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) can lead to spatial memory impairments and hippocampal cell death. Numerous evidence indicates that the antioxidant N-acetylcysteine (NAC) exerts protective effects in the brain. The present study evaluates the effects of NAC on MDMA–induced neurotoxicity. Methods: We intraperitoneally injected 28 adult(More)
Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the protective effects of Borago officinalis (borage) extract on Amyloid β (A β)-Induced memory impairment. Wistar male rats received intrahippocampal (IHP) injection of the A β (25-35) and borage(More)
Alzheimer’s disease (AD) begins with impairment in synaptic functions before developing into later neurodegeneration and neural loss. In the present study we have examined the protective effects of Borago Officinalis (borage) extract on amyloid β (Aβ)—Induced long term potentiation (LTP) disruption in hippocampal dentate gyrus (DG). Wistar male rats(More)
Background: Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objectives: Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ induced memory impairment. Materials and Methods: Wistar(More)
Alzheimer's disease is an age-related neurodegenerative disorder characterized by a progressive decline in cognitive function due to the extracellular accumulation and deposition of beta-amyloid peptide (Aβ). The purpose of this study was to evaluate the protective effect of N-acetyl cysteine (NAC) on learning and memory in an Aβ-induced Alzheimer's disease(More)
The original version of this article unfortunately contained a mistake. Schematic view of hippocampus that illustrates the place of stimulating and recording electrodes is from a published article (Karimi SA, 2013, DOI: 10.1016/j.brainres. 2013.09.029) and reprehensive sample traces of evoked field potential in the DG recorded prior to and 60 min after high(More)
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