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C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
Significance Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) by inducing Ig locus-specific single-strand breaks (SSBs). AID C-terminal mutants (C-mt) generateExpand
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Association between 45T/G Polymorphism of Adiponectin Gene and Coronary Artery Disease in an Iranian Population
A single nucleotide polymorphism (SNP) in the adiponectin gene, 45T/G, has been reported in relation to a number of metabolic disorders, including obesity, insulin resistance, and diabetes. However,Expand
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Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). DuringExpand
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The viral paradigm in type 1 diabetes: Who are the main suspects?
Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of pancreatic beta cells in the islets of Langerhans. Although genetic predisposition plays an important role in T1DExpand
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Tea polyphenols association to caseinate-stabilized oil–water interfaces
Abstract Tea Catechins associate with proline rich proteins such as caseins. In this work, the interactions between epigallocatechin-gallate (EGCG), one of the main tea catechins, and caseins at anExpand
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The AID dilemma: infection, or cancer?
Activation-induced cytidine deaminase (AID), which is both essential and sufficient for forming antibody memory, is also linked to tumorigenesis. AID is found in many B lymphomas, in myeloidExpand
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In vitro digestion of sodium caseinate emulsions loaded with epigallocatechin gallate
Abstract The digestion behaviour of a structured emulsion interface loaded with epigallocatechin-gallate (EGCG) was investigated. Oil in water emulsions were prepared with 0.35% sodium caseinate, 0,Expand
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Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells are destroyed in the islets of Langerhans. One of its main pathological manifestations is the hyper-expression ofExpand
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Alpha cells, the main source of IL-1β in human pancreas.
Interleukin-1β (IL-1β) is known to trigger beta cell dysfunction in vitro and could potentially play a role during the pathogenesis of type 1 diabetes and type 2 diabetes. However, several clinicalExpand
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Association between angiotensin II type 1 receptor gene polymorphism and metabolic syndrome in a young female Iranian population.
BACKGROUND AND AIMS The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascularExpand
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