Soma Guhathakurta

Learn More
Cellular therapy for end-stage liver failures using human mesenchymal stem cells (hMSCs)-derived hepatocytes is a potential alternative to liver transplantation. Hepatic trans-differentiation of hMSCs is routinely accomplished by induction with commercially available recombinant growth factors, which is of limited clinical applications. In the present(More)
A simplified 2D whole heart model (2DWHM) which simulates the Electrocardiogram (ECG) accurately is presented. Although extremely detailed whole heart 3D models are available, they are computationally expensive. On the other hand most of the 2D cardiac models are homogeneous models aiming at modeling activation propagation in a small patch of cardiac(More)
Simulation studies of cardiac arrhythmias at the whole heart level with electrocardiogram (ECG) gives an understanding of how the underlying cell and tissue level changes manifest as rhythm disturbances in the ECG. We present a 2D whole heart model (WHM2D) which can accommodate variations at the cellular level and can generate the ECG waveform. It is shown(More)
Overview: In driving hES cell technology towards widespread applications considerable effort has been focused on the improvement of culture conditions and on enabling efficient differentiation. We have established two technologies which will better enable researchers to achieve these aims. The use of feeder based protocols for the creation, expansion and(More)
  • 1