Solomon F . D Paul

  • Citations Per Year
Learn More
The presence of dicentric chromosome (DC) and micronuclei (MN) frequency in the peripheral blood lymphocytes of 25 cancer patients prior to chemo and radiotherapy and 21 healthy volunteers were studied. The overall DC and MN showed significantly higher frequency compared to those obtained in normal healthy volunteers (p<0.0001). However, among 25 patients(More)
The frequency of micronuclei and acentrics obtained with different doses of 60Co gamma radiation was examined. When compared to acentric frequency the micronuclei frequency was found to be higher at about 115% for doses below 1 Gy. However, it dropped to about 65% as the dose was increased to 4 Gy. This paper discusses the causes for the reduced frequency(More)
The frequency of different biological end-points such as translocation, dicentrics (DC) and micronuclei (MN) was studied in 14 radiation workers and 21 non-radiation workers. The average frequencies for different types of aberrations were significantly higher in radiation workers compared to those of respective aberrations in non-radiation workers. Out of(More)
Unscheduled DNA synthesis (UDS) induced by ultraviolet radiation (UV) was studied in human lymphocytes after exposing blood samples in vitro to doses ranging between 1 and 10 mGy gamma-radiation, by way of measuring tritiated thymidine (3H-TdR) uptake in the DNA of these lymphocytes. The results indicate that samples pre-exposed to gamma-ray doses ranging(More)
Micronucleus (MN) dose-response curves have been studied in blood samples obtained from a healthy volunteer with both a methotrexate synchronised culture and with a conventional culture method. The curve obtained with the synchronised culture, showed better response at higher doses compared to that obtained with the conventional procedure. Generally, MN(More)
Premature Chromosome Condensation (PCC) has been shown to be a powerful cytogenetic and cytokinetic tool in understanding cell-cycle analysis(1) and also for diagnostic purposes(2,3). Although PCC is a useful cytogenetic tool, it involves somatic cell hybridizations employing a mitotic partner. Understanding of the factors responsible for chromatin(More)
Incident High Energy Lasers have shown to cause damages at gross cellular and organelle levels and also at the level of DNA. In this study, the effect of high energy 532 nm short YAG Lasers at 10 pulses per second on circulating lymphocytes was performed. Apart from the damage to the genetic material of the lymphocytes as expressed as “micronuclei”, the(More)
Peripheral blood samples obtained from a normal healthy volunteer were exposed in vitro to gamma radiation with various doses at different dose rates of 1.0, 0.1 and 0.0014 Gy min(-1). The exposed samples were analysed for different chromosomal aberrations such as dicentrics (DC), centric rings (CR) and double-minutes (DM). The ratio of DC chromosomes(More)
  • 1