Solenna Blanchard

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Despite the interest in simultaneous EEG-fMRI studies of epileptic spikes, the link between epileptic discharges and their corresponding hemodynamic responses is poorly understood. In this context, biophysical models are promising tools for investigating the mechanisms underlying observed signals. Here, we apply a metabolic-hemodynamic model to simulated(More)
Developing a clear understanding of the relationship between cerebral blood flow (CBF) response and neuronal activity is of significant importance because CBF increase is essential to the health of neurons, for instance through oxygen supply. This relationship can be investigated by analyzing multimodal (fMRI, PET, laser Doppler…) recordings. However, the(More)
In many physiological or pathological situations, the interpretation of BOLD signals remains elusive as the intimate link between neuronal activity and subsequent flow/metabolic changes is not fully understood. During the past decades, a number of biophysical models of the neurovascular coupling have been proposed. It is now well-admitted that these models(More)
Despite the interest in simultaneous EEG-fMRI studies of epileptic spikes, the link between epileptic discharges and their corresponding hemodynamic responses is poorly understood. We applied two biophysical models in order to investigate the mechanisms underlying the neurovascular coupling in epilepsy: a metabolic hemodynamic model, and a neural mass model(More)
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