Soledad Levano

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Enhanced excitation-coupled Ca(2+) entry induces nuclear translocation of NFAT and contributes to IL-6 release from myotubes from patients with central core disease.

Susan Treves, Mirko Vukcevic, +12 authors Francesco Zorzato
Human molecular genetics
2011

Prolonged depolarization of skeletal muscle cells induces entry of extracellular calcium into muscle cells, an event referred to as excitation-coupled calcium entry. Skeletal muscle… (More)

Increasing the number of diagnostic mutations in malignant hyperthermia.

Soledad Levano, Mirko Vukcevic, +4 authors Thierry Girard
Human mutation
2009

Malignant hyperthermia (MH) is an autosomal dominant disorder characterized by abnormal calcium homeostasis in skeletal muscle in response to triggering agents. Today, genetic investigations on… (More)

Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine.

Soledad Levano, Hans Friedrich Ginz, +4 authors Thierry Girard
Anesthesiology
2005

BACKGROUND Succinylcholine remains the standard neuromuscular blocking drug for tracheal intubation in emergency situations. The short duration of action is due to its rapid hydrolytic degradation by… (More)

Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition

Cristian Setz, Yves Brand, +5 authors Daniel Bodmer
Neuroscience
2011

The matrix metalloproteinases (MMPs) are a family of proteins involved in the remodelling and homeostasis of the extracellular matrix. These proteases have been well studied in the retina and the… (More)

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear

Yves Brand, Soledad Levano, +6 authors Daniel Bodmer
PloS one
2015

The kinase Akt is a key downstream mediator of the phosphoinositide-3-kinase signaling pathway and participates in a variety of cellular processes. Akt comprises three isoforms each encoded by a… (More)

Annexin A1 is a biomarker of T-tubular repair in skeletal muscle of nonmyopathic patients undergoing statin therapy.

Tilman Voigt, Hans-Jörg Sebald, +5 authors Annette Draeger
FASEB journal : official publication of the…
2013

Skeletal muscle complaints are a common consequence of cholesterol-lowering therapy. Transverse tubular (T-tubular) vacuolations occur in patients having statin-associated myopathy and, to a lesser… (More)

Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress

Marijana Sekulic-Jablanovic, Vesna Petkovic, +8 authors Daniel Bodmer
PloS one
2017

Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g.,… (More)

Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro

Yves Brand, Cristian Setz, +7 authors Daniel Bodmer
BMC Neuroscience
2011

Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have… (More)

Loss of STAT1 protects hair cells from ototoxicity through modulation of STAT3, c-Jun, Akt, and autophagy factors

Soledad Levano, Daniel Bodmer
Cell Death and Disease
2015

Hair cell damage is a side effect of cisplatin and aminoglycoside use. The inhibition or attenuation of this process is a target of many investigations. There is growing evidence that STAT1… (More)

A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser.

Thierry Girard, Markus Suhner, Soledad Levano, Martine Singer, Andreas Zollinger, Christoph Karl Hofer
Anesthesia and analgesia
2008

A 37-yr-old patient scheduled for elective bursectomy developed fulminant malignant hyperthermia (MH) under sevoflurane anesthesia. The first sign was a dramatic increase in end-tidal CO(2).… (More)

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