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Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum.
Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC(50) of 3.8+/-0.7microgml(-1) against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line. Expand
Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees.
The crude ethyl acetate extract of M. lutea leaves exhibited significant in vitro anti-parasitic activity and low cytotoxicity against MRC5 and KB cells, and six compounds exhibited mild anti-leishmanial and anti-trypanosomal activities. Expand
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana, where eight showed potent antiplasmodial activity with IC50. Expand
Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda.
Results may indicate a possible explanation of the use of some medicinal plant against malaria in the village of Kiohima and have allowed to highlight a plant with potent antimalarial activity: Citropsis articulata root barks. Expand
Chemical Communication between the Endophytic Fungus Paraconiothyrium Variabile and the Phytopathogen Fusarium oxysporum
Paraconiothyrium variabile, one of the specific endophytic fungi isolated from the host plant Cephalotaxus harringtonia, possesses the faculty to inhibit the growth of common phytopathogens, thusExpand
Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).
A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation. Expand
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
In both series, compounds bearing oxygenated substituents at positions 8 and 9 exhibited cytotoxic properties towards L1210 murine leukemia cells, which may result from their capacities to intercalate into DNA. Expand
The fungal leaf endophyte Paraconiothyrium variabile specifically metabolizes the host-plant metabolome for its own benefit.
Out of more than a thousand molecules present in the crude extract of the plant leaf, a specific biotransformation of glycosylated flavonoids by the endophyte led to the production of the corresponding aglycone via deglycosylation, illustrating the chemical cooperation underlying the mutualistic relationship between the plant and the startophyte. Expand
The marine sponge Plakortis zyggompha: a source of original bioactive polyketides
Abstract Three new spiculoic acids 1 – 3 and two members of a new closely related family of natural products named zyggomphic acids 4 and 5 were isolated from the very little studied marine spongeExpand
Chemical Composition and Antibacterial Activity of Pituranthos Chloranthus Volatile Oil
The chemical composition of the essential oil of Pituranthos chloranthus ssp. cossonianus Maire (Apiaceae) was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS)Expand