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  • Soichi Takiguchi, Eiji Kumazawa, Takao Shimazoe, Akiko Tohgo, Akira Kono
  • Biology, Medicine
  • Japanese journal of cancer research : Gann
  • 1997 (First Publication: 1 August 1997)
  • DX-8951 is a novel water-soluble derivative of camptothecin. We evaluated the effects of DX-8951 on the growth of several pancreatic tumor cell lines in vitro and in vivo. In vitro cytotoxic activityContinue Reading
  • Yukio Nishimura, Soichi Takiguchi, Shigeru Itō, Kazuyuki Itoh
  • Biology, Medicine
  • International journal of oncology
  • 2015 (First Publication: 1 April 2015)
  • The receptor tyrosine kinase epidermal growth factor receptor (EGFR) and its ligand epidermal growth factor (EGF) are known to play important roles in malignant tumor cells, and the EGFR signalingContinue Reading
  • Yukio Nishimura, Soichi Takiguchi, Kiyoko Yoshioka, Yusaku Nakabeppu, Kazuyuki Itoh
  • Biology, Medicine
  • International journal of oncology
  • 2012 (First Publication: 1 October 2012)
  • Gefitinib is known to suppress the activation of EGFR signaling, which is required for cell survival and proliferation in non-small cell lung cancer (NSCLC) cell lines. We previously demonstratedContinue Reading