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Tocilizumab: a review of its use in the management of rheumatoid arthritis.
TLDR
Tocilizumab-based therapy was consistently more effective than placebo, methotrexate or other DMARDs in reducing disease activity, and some trials also showed significant benefits with tocilizumAB in terms of reducing structural joint damage and improving health-related quality of life (HR-QOL). Expand
Sitagliptin: a review of its use in the management of type 2 diabetes mellitus.
TLDR
Current evidence suggests that sitagliptin is a useful treatment option for patients with type 2 diabetes, with potential advantages including oral administration, a generally weight-neutral effect and a low risk of hypoglycaemia. Expand
Atazanavir: a review of its use in the management of HIV-1 infection.
TLDR
Atazanavir, whether unboosted or boosted, was generally well tolerated and appeared to be associated with less marked metabolic effects, including less alteration of lipid levels, than other PIs, and continues to have a role as a component of ART regimens in patients with HIV-1 infection. Expand
Bupropion: a review of its use in the management of major depressive disorder.
TLDR
Available clinical data suggest that bupropion is an effective and generally well tolerated option in the treatment of MDD, with the newer formulations having the advantage of reduced frequency of daily administration. Expand
Epi proColon® 2.0 CE: A Blood-Based Screening Test for Colorectal Cancer
TLDR
Limited data suggest that Epi proColon® 2.0 CE has the potential to be a sensitive and convenient screening option for patients refusing screening by colonoscopy, and large prospective trials of the test in a screening setting will be required to further elucidate the cost-effectiveness. Expand
Roxadustat: First Global Approval
TLDR
The milestones in the development of roxadustat are summarized, leading to this first approval, for the treatment of anaemia in patients with dialysis-dependent chronic kidney disease, and studies are underway to investigate long-term cardiovascular outcomes. Expand
Intravenous Tocilizumab: A Review of Its Use in Adults with Rheumatoid Arthritis
TLDR
Current evidence indicates that tocilizumab is effective as a first- or subsequent-line biologic in patients with moderate to severe rheumatoid arthritis. Expand
Etanercept: a review of its use in the management of rheumatoid arthritis.
TLDR
Etanercept plus methotrexate combination therapy was generally superior to either monotherapy or combination therapy in reducing disease activity and structural joint damage, as well as improving health-related quality of life (HR-QOL). Expand
Dinutuximab: First Global Approval
TLDR
The milestones in the development of dinutuximab leading to this first approval for use in the treatment of paediatric patients with high-risk neuroblastoma who achieve at least partial response to prior first-line multiagent, multimodality therapy are summarized. Expand
Escitalopram: a review of its use in the management of anxiety disorders.
Escitalopram (Cipralex, Lexapro, Seroplex, Sipralexa), the therapeutically active S-enantiomer of racemic citalopram (RS-citalopram), is a potent and highly selective serotonin reuptake inhibitor. ItExpand
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