Sofie Elisabeth Midgley

Learn More
Group A rotaviruses can infect both humans and animals. Individual rotavirus strains can occasionally cross species barriers and might hereby contribute to the emergence of new genotypes in heterologous hosts. The incidence and impact of zoonotic rotavirus are not well defined, and one reason for this is a lack of data about strains circulating in suspected(More)
Hepatitis B virus (HBV) infection is widely distributed in both human and ape populations throughout the world and is a major cause of human morbidity and mortality. HBV variants are currently classified into the human genotypes A to H and species-associated chimpanzee and gibbon/orangutan groups. To examine the role of recombination in the evolution of(More)
Since its discovery in California in 1962, reports of enterovirus D68 have been infrequent. Before 2014, infections were confirmed in only 699 people worldwide. In August, 2014, two paediatric hospitals in the USA reported increases in the number of patients with severe respiratory illness, with an over-representation in children with asthma. Shortly after,(More)
BACKGROUND Sapoviruses are known to cause gastroenteritis mainly in young children. OBJECTIVES To establish a collection of sapoviruses and to gain knowledge about the genetic diversity and epidemiology of sapoviruses circulating in children in Denmark. STUDY DESIGN During a 24-month period in 2005-2007 samples from 1104 children, aged 0-3 years,(More)
As the number of new enteroviruses and human parechoviruses seems ever growing, the necessity for updated diagnostics is relevant. We have updated an enterovirus assay and combined it with a previously published assay for human parechovirus resulting in a multiplex one-step RT-PCR assay. The multiplex assay was validated by analysing the sensitivity and(More)
Human parechoviruses (HPeVs) often cause severe illness among young children. National surveillance with routine testing of all cerebrospinal fluid, fecal, and tissue samples was conducted during January 2009-December 2012 in all counties in Denmark (6,817 samples from 4,804 children were screened for HPeV). We detected HPeV RNA in 202 (3.0%) specimens from(More)
BACKGROUND Since the late 1990s enterovirus 71 (EV71) has caused epidemics of hand, foot and mouth disease with fatal cases especially in the Asian Pacific region. The objective of this study was to describe the clinical and virological features of EV71 infections in Denmark. METHODS All enterovirus-positive samples in Denmark are submitted to the(More)
To the Editor: Hepatitis E virus genotype 4 (HEV4) is most commonly reported in China and Japan; it has primarily been categorized as a zoonotic virus because it has been found in humans and several other animal species (1). In Europe, HEV4 has been identified in 6 countries, in humans and other animals. The first cases of HEV4 infection in a human and an(More)
confirmed cases of hepatitis A virus (HAV) infections with subgenotype IB and identical RNA sequence, and 89 probable cases, have been reported in 14 EU/EFTA countries. All cases have a travel history to Egypt. Due to the fact that 15 of these cases, identified in three different countries, have identical sequences, a multistate outbreak has been confirmed(More)
The primary aim of the Danish enterovirus (EV) surveillance system is to document absence of poliovirus infection. The conflict in Syria has left many children unvaccinated and movement from areas with polio cases to Europe calls for increased awareness to detect and respond to virus-transmission in a timely manner. We evaluate the national EV laboratory(More)