Sofia Svensson

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Interconversion between cortisone and the glucocorticoid receptor ligand cortisol is carried out by 11β-hydroxysteroid dehydrogenase (11β-HSD)isozymes and constitutes a medically important example of pre-receptor control of steroid hormones. The enzyme 11β-HSD type 1 (11β-HSD1) catalyzes the conversion of cortisone to its active receptor-binding derivative(More)
Bladder cancer associated protein (Blcap) expression is commonly down-regulated in invasive bladder cancer, and may have prognostic value given that its expression is negatively correlated with patient survival. We have previously investigated the expression patterns and cellular localization of Blcap in bladder cancer, where we found that about 20% of the(More)
The human alcohol dehydrogenase system is comprised of multiple forms that catalyse the oxidation/reduction of a large variety of alcohols and aldehydes. A transition that results in an Ile308Val substitution was identified in the human ADH2 gene by single-strand conformation polymorphism analysis. Screening a Swedish population revealed that Val308 was the(More)
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