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Preoperative chemoradiotherapy (CRT) is the cornerstone of treatment for locally advanced rectal cancer (LARC). Although high local control is achieved, overall rates of distant control remain suboptimal. Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin pathway involved in proliferation and survival. The aim of this(More)
This paper seeks to shed light on the question of the likely evolution of collective bargaining in Europe under EMU by considering the experiences of two countries (Italy and Spain) in which governments and social actors attempted to decentralized collective bargaining during the 1980s only to opt in favor of a re-centralization of bargaining during the(More)
This paper presents ongoing research on a new approach to structure and elicit improvement opportunities in the software development process followed by technical-scientific teams. The bottom-up approach has been proved as more effective in process improvement applied to technical and scientific environments, in opposition to standard improvement models(More)
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