Sofia Håkansson

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Here we describe a new route to site- and class-specific protein modification that will allow us to create novel functional proteins with artificial chemical groups. Glutathione transferases from the alpha but not the mu, pi, omega, or theta classes can be rapidly and site-specifically acylated with thioesters of glutathione (GS-thioesters) that are similar(More)
During the course of the research underlying this thesis, Sofia Håkansson Hederos was enrolled in Forum Scientium, a multidisciplinary graduate school funded by the Swedish Foundation for Strategic Research (SSF) and Linköpings universitet, Sweden. Abstract This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from(More)
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