Learn More
AIM To assess the efficacy of automated "disease/no disease" grading for diabetic retinopathy within a systematic screening programme. METHODS Anonymised images were obtained from consecutive patients attending a regional primary care based diabetic retinopathy screening programme. A training set of 1067 images was used to develop automated grading(More)
BACKGROUND During pregnancy the maternal choroid is exposed to the multiple haemodynamic and hormonal alterations inherent to this physiological condition. These changes may influence choroidal anatomy. In this study a quantitative assessment of overall choroidal structure is performed, by constructing a 3-dimensional topographic map of this vascular bed.(More)
PURPOSE To evaluate the changes of vascular endothelial growth factor (VEGF) plasma levels after intravitreal injections of ranibizumab or bevacizumab in patients with exudative age-related macular degeneration (AMD). METHODS Forty-three patients with exudative AMD and 19 age- and sex-matched control patients without chorioretinal diseases were studied.(More)
AIMS National screening programmes for diabetic retinopathy using digital photography and multi-level manual grading systems are currently being implemented in the UK. Here, we assess the cost-effectiveness of replacing first level manual grading in the National Screening Programme in Scotland with an automated system developed to assess image quality and(More)
BACKGROUND/AIMS To compare retrospectively the incidence of arterial thromboembolic events (ATEs) in patients treated with bevacizumab or ranibizumab for exudative age-related macular degeneration. METHODS Charts of 378 patients treated with at least 1 intravitreal injection of ranibizumab or bevacizumab were reviewed to calculate the incidence of ATEs.(More)
PURPOSE To determine the topographic distribution and progression of geographic atrophy (GA) in patients with AMD. METHODS Fundus autofluorescence images (excitation 488, emission 500-700 nm) from 413 eyes of 413 subjects (median age, 77.0 years; inter quartile range [IQR], 72.0-82.0 years) of the Geographic Atrophy Progression (GAP) study were(More)
PURPOSE We compared the efficacy of intravitreal ranibizumab and bevacizumab for treating neovascular age-related macular degeneration using an on-demand regimen. METHODS A total of 186 wet age-related macular degeneration eyes of 186 treatment-naïve patients were compared retrospectively (67 eyes treated with ranibizumab with 91 treated with(More)
Cytomegalovirus (CMV) retinitis may occur in profoundly immunocompromised patients and be the initial AIDS-defining infection. The incidence and prevalence of CMV retinitis has declined substantially in the era of highly active antiretroviral therapy (HAART); nevertheless, it remains a leading cause of ocular morbility. We report the case of a 40-year-old(More)
Purpose: To evaluate the peripapillary retinal nerve fiber layer (RNFL) in Wolfram's Syndrome (WS) using optical coherence tomography (OCT). Methods: The peripapillary RNFL of eighteen eyes of nine patients with the clinical diagnosis of WS were measured using Stratus OCT. The RNFL was determined consecutively three times. Results: The mean RNFL thickness(More)
PURPOSE To report a case of uncontrolled proliferative diabetic retinopathy as an initial manifestation of chronic myeloid leukemia. METHODS Case report. PATIENTS A 55-year-old man with moderate nonproliferative diabetic retinopathy who rapidly developed proliferative retinopathy and bilateral neovascular glaucoma despite good glycemic control. (More)