Sofía D. Merajver

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Cycles involving covalent modification of proteins are key components of the intracellular signaling machinery. Each cycle is comprised of two interconvertable forms of a particular protein. A classic signaling pathway is structured by a chain or cascade of basic cycle units in such a way that the activated protein in one cycle promotes the activation of(More)
In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT Biological signal transduction networks are commonly viewed as circuits that pass-along information-in the process amplifying, enhancing sensitivity, or performing other signal-processing tasks-to transcriptional and other(More)
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