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OBJECTIVE Can gestational weight gain in obese women be restricted by 10-h dietary consultations and does this restriction impact the pregnancy-induced changes in glucose metabolism? DESIGN A randomized controlled trial with or without restriction of gestational weight gain to 6-7 kg by ten 1-h dietary consultations. SUBJECTS Fifty nondiabetic(More)
OBJECTIVE To study the effect on weight loss in obese subjects by replacement of carbohydrate by protein in ad libitum consumed fat-reduced diets. DESIGN Randomized dietary intervention study over six months comparing two ad libitum fat reduced diets (30% of total energy) strictly controlled in composition: High-carbohydrate (HC, protein 12% of total(More)
BACKGROUND Observational studies have shown an inverse association between dietary calcium intake and body weight, and a causal relation is likely. However, the underlying mechanisms are not understood. OBJECTIVE We examined whether high and low calcium intakes from mainly low-fat dairy products, in diets high or normal in protein content, have effects on(More)
BACKGROUND Previous studies have indicated that the secretion of the intestinal satiety hormone glucagon-like peptide-1 (GLP-1) is attenuated in obese subjects. OBJECTIVE To compare meal-induced response of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) in obese and lean male subjects, to investigate the effect of a major weight reduction in(More)
BACKGROUND Studies of long-term intake of industrially produced trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (PUFA) suggest opposite effects on cardiovascular disease risk. Common mechanisms of action are probable. OBJECTIVE To examine the effects on cardiovascular risk markers of dietary enrichment with TFA or n-3 PUFA. DESIGN(More)
OBJECTIVE Low birth weight (LBW), a marker of disturbed fetal growth, is associated with adiposity and increased risk of type 2 diabetes (T2D). The aim of the study was to investigate whether LBW is associated with changes in 24-h energy expenditure (EE) and/or substrate utilization rates, potentially contributing to the development of adiposity and/or T2D(More)
BACKGROUND Single-meal tests have shown that protein has greater thermogenic and satiating effects than does carbohydrate, which may be relevant for the prevention and treatment of obesity if these effects can be maintained over 24 h. OBJECTIVE The effects of pork-meat protein, soy protein, and carbohydrate on 24-h energy expenditure were compared. (More)
BACKGROUND We have previously reported that a fat-reduced high-protein diet had more favourable effects on body weight loss over 6 months than a medium-protein diet. OBJECTIVE To extend this observation by a further 6-12 months less stringent intervention and a 24 months follow-up. DESIGN A randomised 6 months strictly controlled dietary intervention(More)
BACKGROUND Due to the high satiating effect of protein, a high-protein diet may be desirable in the treatment of obesity. However the long-term effect of different levels of protein intake on renal function is unclear. OBJECTIVE To assess the renal effects of high vs low protein contents in fat-reduced diets. DESIGN Randomized 6 months dietary(More)
OBJECTIVE To investigate the contribution of beta 3-adrenoceptor activation to sympathetic stimulation of thermogenesis in humans using a sympathomimetic (ephedrine) in combination with a non-selective beta-adrenoceptor antagonist (nadolol). DESIGN Three doses (2.5, 5 and 10 mg) of nadolol were used to estimate what fraction of the thermogenic response to(More)