• Publications
  • Influence
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
LRRK2 kinase inhibitors, under development for Parkinson’s disease, have an effect on type II pneumocytes in nonhuman primate lung, suggesting that pulmonary toxicity may be a critical safetyExpand
  • 180
  • 11
Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.
PURPOSE To determine if the progression of age-related macular degeneration (AMD) is associated with complement activation in the eye. METHODS Immunohistochemistry and ELISAs were used to determineExpand
  • 51
  • 3
  • PDF
Survey and comparison of major intestinal flora in captive and wild ring‐tailed lemur (Lemur catta) populations
A survey to identify the major intestinal species of aerobic bacteria, protozoa and helminths was conducted on captive and wild populations of ring‐tailed lemurs (Lemur catta). Samples were collectedExpand
  • 30
  • 2
Bruton’s Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats
Bruton’s tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated forExpand
  • 7
  • 2
A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum.
Electrochemiluminescence (ECL) assays have been widely used for the detection of anti-therapeutic antibodies (ATAs) against biotherapeutics. With the discontinuation of BioVeris (BV) ECL platform, anExpand
  • 22
  • 1
Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.
Inhibitor-of-apoptosis (IAP) proteins suppress apoptosis and are overexpressed in a variety of cancers. Small-molecule IAP antagonists are currently being tested in clinical trials as novel cancerExpand
  • 32
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
The structure of the Fab region of antibodies is critical to their function. By introducing single cysteine substitutions into various positions of the heavy and light chains of the Fab region ofExpand
  • 22
  • PDF
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.
MEK, a kinase downstream of Ras and Raf oncogenes, constitutes a high priority target in oncology research. MEK small molecule inhibitors cause soft tissue mineralization in rats secondary to serumExpand
  • 18
  • PDF
Influence of the compound selection process on the performance of human clearance prediction methods.
This is a commentary on the series of five manuscripts written as part of the Pharmaceutical Research and Manufacturers of America Clinical and Preclinical Development Committee initiative onExpand
  • 5
Heteroscedastic factor analysis
Two moment-based model-fitting procedures for the heteroscedastic factor analysis model are introduced and compared. The procedures produce consistent parameter estimators and asymptotically validExpand
  • 8