Sobha Sivaprasad

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AIMS To compare the prevalence of diabetic retinopathy (DR) in people of various ethnic groups with diabetes in the United Kingdom (UK). METHODS The Diabetic Retinopathy In Various Ethnic groups in UK (DRIVE UK) Study is a cross-sectional study on the ethnic variations of the prevalence of DR and visual impairment in two multi-racial cohorts in the UK.(More)
This study aimed to investigate the clinical features of newly diagnosed type 2 diabetes in an urban multi-ethnic cohort. A population-based cross-sectional design was used. People diagnosed with type 2 diabetes in the preceding 6 months were recruited from primary care practices in three adjacent inner-city boroughs of South London, serving a population in(More)
AIM The study was a prospective randomised controlled double-masked trial performed in two centres to compare sub-threshold micropulse diode laser photocoagulation (MPDL) with conventional green laser photocoagulation (CGL) in the treatment of clinically significant diabetic macular oedema (CSMO). METHODS Fifty-three patients (84 eyes) with diabetic CSMO(More)
PURPOSE To compare the functional and structural effects of ranibizumab versus macular laser therapy in patients with center-involving diabetic macular edema. DESIGN Prospective, randomized, single-masked clinical trial. METHODS SETTING Single center. STUDY POPULATION Thirty-three eyes of 33 patients with center-involving diabetic macular edema,(More)
INTRODUCTION Exudative form of age-related macular degeneration is the leading cause of legal blindness in elderly. PURPOSE The purpose of this study is to report 3.5 years experience with photodynamic therapy in this disorder. PATIENTS AND METHODS Patient files of all patients underwent photodynamic therapy with verteporfin in Department of(More)
BACKGROUND Abnormalities in rod and cone photoreceptor morphology have been reported in normal aging retinas in the absence of known pathology and have been taken as an indicator of susceptibility to retinal disease. Some loss of visual performance may therefore precede retinal structural changes that can be detected reliably using conventional fundus(More)
BackgroundLarge clinical trials have emphasized that blood pressure control provides a major clinical benefit in reducing the risk of blindness in patients with diabetic retinopathy.MethodsThis audit was carried out to assess the quality of care for hypertension in 100 consecutive type II diabetics with diabetic retinopathy.ResultsThe target blood pressure(More)
RATIONALE MicroRNA (miRNA) biomarkers are attracting considerable interest. Effects of medication, however, have not been investigated thus far. OBJECTIVE To analyze changes in plasma miRNAs in response to antiplatelet therapy. METHODS AND RESULTS Profiling for 377 miRNAs was performed in platelets, platelet microparticles, platelet-rich plasma,(More)
AimsTo evaluate the efficacy and safety of intravitreal ranibizumab in patients with choroidal neovascularisation secondary to pathological myopia (myopic CNV). Data are from a pre-planned, 6-month interim analysis.MethodsPhase II, open-label, single arm, multicentre, 12-month study, recruiting patients (aged ≥18 years) with active primary or recurrent(More)
PURPOSE Aflibercept has the potential advantage of reducing capacity problems by allowing 2 monthly visits for patients with neovascular macular degeneration (nAMD) compared with monthly pro re nata regimens that are the most commonly used in the United Kingdom. This study aimed to report the visual outcomes achieved in routine clinical practice using the(More)