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Meckel syndrome (MIM 249.000) is an autosomal recessive disorder with a variable spectrum of anomalies. Since the first reports of this syndrome, very broad diagnostic criteria have been proposed, but the process of defining them continues. It is probable that at least two of three manifestations, including cystic kidney dysplasia, occipital encephalocele(More)
From 12 weeks of gestation on, a progressive remodeling of the human primitive biliary structure or ductal plate occurs. A few parts of the primitive biliary structure (peripheral tubular or ductular structures) dilate, migrate toward the center of the portal tract, and transform into mature bile ducts, while most of them gradually disappear. To the best of(More)
A HPLC-method was developed for the simultaneous detection of the lipophilic antioxidants ubiquinol-10, ubiquinone-10, alpha-tocopherol, and gamma-tocopherol in plasma macrosamples (100 microl) as well as microsamples (10 microl) using electrochemical detection with internal standardization (gamma-tocotrienol, ubiquinol-9, ubiquinone-9). The use of a mobile(More)
We describe four cases of acardius (one of hemiacardius, two of holoacardius acephalus, and one of the holacardius amorphus) and present the current range of therapeutic possibilities: control of amniotic fluid by repeated amniocentesis or indomethacin therapy, administration of digoxin to the mother, selective preterm delivery of the acardiac twin by(More)
Bone morphogenetic proteins (BMPs) are multifunctional cytokines. BMP-6 is involved in early steps of keratinogenesis. Esophageal squamous-cell carcinoma often shows abnormal keratinization. The aim of this study was to examine the expression and regulation of BMP-6 in esophageal carcinoma and to determine the relationship of its expression with tumor(More)
In an unpredictable world where human intervention or unexpected environmental conditions can prevail, damage can occur to manmade structures. Whilst structural design allows for redundancy, or a structural capability beyond the general working load of the structure, it is necessary to be able to analyse and understand the residual capability of a damaged(More)
INTRODUCTION Since the first description of two children affected with human immunodeficiency virus (HIV), various diagnostic procedures have been established. However, the morphologic study of biopsy and autopsy material from children with acquired immunodeficiency syndrome (AIDS) is still of fundamental importance. The morphology has contributed(More)
Triploidy is constituted by an extra haploid set of chromosomes for a total of 69 chromosomes in humans. A "parent-of-origin" effect has been demonstrated by analysis of cytogenetic polymorphisms of triploidy pregnancies. Two distinct phenotypes of human triploid fetuses have been recognized according to the parental origin of the extra haploid set. The(More)
An einem eigenen Fall und anhand der Literatur besprechen die Autoren die histopathologischen Ergebnisse im Bereich des sog. ruhenden Knorpels und der Epiphysenfuge der selten auftretenden diastrophischen Dysplasie. Außerdem wird die Differentialdiagnose zum pseudodiastrophischem Kleinwuchs und zur Atelosteogenese Typ II tabellarisch dargestellt. The(More)