So Ra Lee

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E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal(More)
A 14-membered macrolide antibiotic narbomycin produced from Streptomyces venezuelae ATCC 15439 is composed of polyketide macrolactone ring and D-desosamine as a deoxysugar moiety, which acts as an important determinant of its antibacterial activity. In order to generate diverse glycosylated derivatives of narbomycin, expression plasmids carrying different(More)
Recommended Citation Lee, So Ra. "Pharmacological and biophysical characterization of a prokaryotic voltage-gated sodium channel." PhD (Doctor of Philosophy) thesis, ii To my family iii ACKNOWLEDGEMENTS First and foremost, I would like to express my sincere gratitude to my supervisor Dr. Christopher A. Ahern for his continuous support, guidance,(More)
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