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Tumor lysis syndrome is an oncologic emergency that is characterized by severe electrolyte abnormalities and, frequently, by acute renal failure. The syndrome typically occurs in patients with lymphoproliferative malignancies, most often after initiation of treatment. The pathophysiology involves massive tumor cell lysis resulting in the release of large(More)
In this paper we show how data integration techniques can be used to automatically compose new web services from existing web services. A key challenge is to optimize the execution of the composed web services. We introduce a novel technique termed tuple-level filtering that optimizes the execution of the composed web services by reducing the number of web(More)
BACKGROUND Lenalidomide (LEN) is a structural and functional analogue of thalidomide that has demonstrated enhanced immunomodulatory properties and a more favorable toxicity profile. A Phase II, open-label study of LEN in patients with metastatic renal cell carcinoma (RCC) was conducted to determine its safety and clinical activity. METHODS Patients with(More)
Building Finder uses semantic Web technologies to integrate different data types from various online data sources. The application's use of the RDF and RDF data query language makes it usable by computer agents as well as human users. An agent would send a query, expressed in terms of its preferred ontology (schema), to a system that would then find and(More)
The emergence of a large number of bioinformatics datasets on the Internet has resulted in the need for flexible and efficient approaches to integrate information from multiple bioinformatics data sources and services. In this paper, we present our approach to automatically generate composition plans for web services, optimize the composition plans, and(More)
from Microsoft Research. 2 Proteus is a Greek sea god with the ability to change shape at will and predict the future. Abstract Many organizations envision web services as an enabling component of Internet-scale computing. A final vision of web s ervices is to realize a dynamic environment that identifies, composes and executes web services in response to a(More)
BACKGROUND The presence of alloantibodies and/or alloreactive T cells in a patient prior to a transplant can impact graft outcome. Environmental factors, including therapeutic vaccinations, may influence the strength and/or specificity of alloimmunity. METHODS To address this issue, we prospectively evaluated the effects of two different immunization(More)
Osteonecrosis of the jaw has been linked with bisphosphonate use in breast cancer and multiple myeloma patients. We report 17 cases of patients with plasma cell dyscrasia being treated with bisphosphonate who developed osteonecrosis/osteomyelitis of the jaw. Seventeen patients evaluated at our institution between 1998 and 2005 are reported. All were being(More)
The standard approach for relapsed diffuse large B-cell lymphoma (DLBCL) involves auto-SCT. However, studies that established this approach were conducted before the inclusion of rituximab (R) with first-line therapy became routine. Whether DLBCL patients (pts) relapsing after first-line chemoimmunotherapy including R derive a comparable benefit from(More)