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Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including the lung malignancy. Genetic modifications such as deletions, insertions and Single Nucleotide Polymorphisms in the tyrosine kinase (TK) domain of EGFR is a common feature observed in most lung cancers. Gefitinib and erlotinib are commonly available(More)
BACKGROUND Gastric electric stimulation (GES) at a high-frequency, low-energy setting is an option for treating refractory gastroparesis. The currently available commercial stimulator, the Enterra neurostimulator (Medtronic Inc, Minneapolis, MN), however, requires surgical implantation and is powered by a nonrechargeable battery. OBJECTIVE To develop and(More)
— In this work, we developed a dual-sensor system to monitor the symptoms in gastroesophageal reflux disease (GERD). The system consists of an implantable transponder and an external reader. The passive telemetry for signal transduction is based on an inductive link between two coil antennas. The reader supplies radio frequency power, obtains and stores the(More)
Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a(More)
This paper presents design and optimization methods for spiral coils utilized for wireless power transfer in wireless medical implant applications. A theoretical model was examined for near-field distributions of spiral-type transmitter antennas in both orthogonal components. Finite-element simulations were performed to verify the theoretical radiation(More)
In this study, a device for gastroesophageal reflux disease (GERD) monitoring has been prototyped. The system consists of an implantable, batteryless and wireless transponder with integrated impedance and pH sensors; and a wearable, external reader that wirelessly powers up the transponder and interprets the transponded radio-frequency signals. The(More)
— This study investigated wireless power transfer with inductive coupling at a distance addressing the power requirement for chronic gastrostimulator implants. The energy harvesting system was designed to collect 3 to 20 mW power to operate an implantable stimulator to deliver 1 to 6 mA electric current into stomach tissues. The power transfer system(More)
— Implantable devices are currently used regularly for chronic pain relief, cardiac pacemakers, arterial infusion for cancer and insulin delivery. A MEMS based implantable drug delivery system (IDDS) integrating a subcutaneous reservoir, an in plane silicon pump and associated circuitry for local or centralized delivery of therapeutic agents for(More)
In this paper, we report a power management system for autonomous and real-time monitoring of the neurotransmitter L-glutamate (L-Glu). A low-power, low-noise, and high-gain recording module was designed to acquire signal from an implantable flexible L-Glu sensor fabricated by micro-electro-mechanical system (MEMS)-based processes. The wearable recording(More)
Staphylococcus aureus has one essential type I signal peptidase (SPase), SpsB, which has emerged as a potential target in the search for antibiotics with a new mode of action. In this framework, the biochemical properties of SpsB are described and compared with other previously characterized SPases. Two different substrates have been used to assess the in(More)