Smita Rindhe

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KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coenzyme A (CoA) synthetase long-chain(More)
The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell survival. FAK has previously been reported to undergo nuclear localization during cell migration, cell(More)
The protein inhibitor of activated STAT-1 (PIAS1) is one of the few known SUMO E3 ligases. PIAS1 has been implicated in several biological processes including repression of innate immunity and DNA repair. However, PIAS1 function during development and tissue differentiation has not been studied. Here, we report that Pias1 is required for proper embryonic(More)
A total of 103 samples of poultry of different age groups of non specific infections were tested. The cultural examination revealed presence of the organisms in descending order E. coli, Staphylococci, Enterobactor, Pseudomonas, Bacillus, Streptococci and Klebsiella. Antibiogram of these samples showed Chloramphenicol, Gentamicin and Ampicillin as most(More)
Present study was aimed to develop acceptable shelf stable chicken sausages using textured soya protein as a humectants and lactic acid as a acidulent along with the use of Nisin to extend the shelf life of hurdle treated chicken sausages. Chicken sausage was prepared from emulsion of minced and chopped meat along with addition of non meat ingredients such(More)
*Department of Internal Medicine and Simmons, Comprehensive Cancer Center, University of Texas, Southwestern Medical Center, Dallas, TX, USA; Department of Pulmonary Medicine, The First Affiliated Hospital of Sun, Yat-sen University, Guangzhou, Guangdong, China; Department of Translational Molecular Pathology, Head & Neck Medical Oncology, The University of(More)
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