Smita K Baid

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CONTEXT Cushing's syndrome (CS) is associated with symptoms that may impair health-related quality of life (HRQL). METHODS We used the short-form 36 survey to evaluate HRQL in 23 patients with Cushing's disease before and after transsphenoidal surgery (age, 42.7 +/- 12.0 yr; 19 women and four men) and in a cross-section of 343 CS patients (age, 48.2 +/-(More)
CONTEXT Recent reports suggest a higher prevalence (1-5%) of Cushing's syndrome in certain patient populations with features of the disorder (e.g., diabetes), but the prevalence in the overweight and obese population is not known. OBJECTIVE The aim of the study was to evaluate the diagnostic performance of screening tests for Cushing's syndrome in(More)
CONTEXT Although bedtime salivary cortisol measurement has been proposed as the optimal screening test for the diagnosis of Cushing's syndrome, its performance using commercially available assays has not been widely evaluated. OBJECTIVE Our objective was to compare RIA and tandem mass spectrometry (LC-MS/MS) measurement of salivary cortisol in obese(More)
OBJECTIVE To examine the factors causing inadequate cortisol responses to the 1 microg ACTH stimulation test. DESIGN Random test assignment (by age and gender) at 0800 or 1600 h. METHODS We recruited 20 healthy adults to each of the three age groups (<40 years, 40-55 years, and >55 years; half females in each group). ACTH stimulation tests were(More)
Glucocorticoids can cause adverse systemic side-effects ranging from iatrogenic Cushing's syndrome during treatment, to hypothalamic-pituitary-adrenal axis suppression and clinically significant adrenal insufficiency when the agents are discontinued. While the oral route of administration is most often implicated, it is now becoming more apparent that(More)
In patients with primary hyperaldosteronism, adrenal vein sampling (AVS) has emerged as a gold standard for distinguishing between unilateral and bilateral disease, but multiple criteria have been used and no consensus exists as to the most accurate criterion. The objective of this study was to determine which AVS criteria most accurately identify patients(More)
BACKGROUND In patients with primary hyperaldosteronism, distinguishing between unilateral and bilateral adrenal hypersecretion is critical in assessing treatment options. Adrenal venous sampling (AVS) has been advocated by some to be the gold standard for localization of the responsible lesion, but there remains a lack of consensus for the criteria and the(More)
Technical details influence the diagnostic accuracy of the 1 mg ACTH stimulation test Matthew Wade, Smita Baid, Karim Calis, Hershel Raff, Ninet Sinaii and Lynnette Nieman Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development and Pharmacy Department, National Institutes of Health, Clinical Center, Building(More)
Cushing's syndrome is a rare disorder characterized by chronic, excess glucocorticoid exposure. Hypertension is one of the most discriminating features of the disease, as it is present in 80% of patients. Patients with Cushing's syndrome have a mortality rate four times that of the general population, most likely secondary to an increased number of(More)