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Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival
Significance MicroRNAs (miRNAs) can regulate the amounts of specific proteins by targeting their mRNA. miR-504, which targets the mRNA encoding the p53 tumor suppressor, resides within an intron ofExpand
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Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint
Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53 through the RPL5/RPL11/5S rRNA complex-mediated inhibition of HDM2. Studies using animal modelsExpand
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New insights into HEATR1 functions
Human HEAT repeat containing 1 protein (HEATR1) is the structural and functional homolog of yeast U3 small nucleolar RNA-associated protein 10 (UTP 10) [1].UTP 10 was originally identified as aExpand
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RIBOSOMAL PROTEINS L5 AND L11 PARTICIPATE IN ACTIVATION OF THE P53 TUMOR SUPPRESSOR IN RESPONSE TO MANY DIFFERENT STRESSES
The capacity of p53 protein to detect and appropriately respond to many cancer-related stresses is essential for prevention of malignancies in humans. Although it is not known how such diversity ofExpand
Uloga ribosomskih proteina u aktivaciji supresora tumora p53 : doktorski rad
Ciljevi istraživanja: Na temelju rezultata istraživanja u zadnjih desetak godina predložen je model u kojem inhibicija sinteze ribosoma rezultira
Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer.
Ribosome biogenesis (RiBi) is one of the most complex and energy demanding processes in human cells, critical for cell growth and proliferation. Strong causal links between inherited and acquiredExpand