Skaidrite Germane

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Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal alpha-MSH instead gave a short-term(More)
Effects of a Hypericum extract in therapeutic use and hyperforin sodium salt were evaluated in rat and mouse avoidance tests. In a conditioned avoidance response (CAR) test on the rat, oral daily administration of hyperforin (1.25 mg/kg/day) or of the extract (50 mg/kg/day) before the training sessions considerably improved learning ability from the second(More)
Glutapyrone, a disodium salt of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido)- glutaric acid, is a representative of a novel 'class' of amino acid-containing 1,4-dihydropyridine (DHP) compounds developed at the Latvian Institute of Organic Synthesis, Riga, Latvia. Conceptually, the glutapyrone molecule can be regarded as a(More)
12. T. W. Nilsen and C. Baglioni, Proc. Nat. Acad. Sci. USA, 76, N_ o 6, 2600-2604 (1979). 13. T. W. Nilsen, P. A? Maroney, and C. Bagliord, J. Virol., 42, 1039 (1982). 14. S. Pestka, J. A. Langer, K. Zoon, and C. E. Samuel, Ann. Rev. Biochem., 56, 727-777 (1987). i5. N. B. K. Ray and P. M. Pitha, Proc. Nat. Acad. Sci. USA, 80, 3923-3927 (1983). 16. B. Y.(More)
Also examined were the tolerance of white mice for (VII), and its therapeutic activity in experimental tuberculosis in white mice. The maximum tolerated dose following a single intragastric daily dose for five days was found to be greater than 2000 mg/kg. Treatment of mice with experimental tuberculosis for 39 days with a range of doses of the compound(More)
By the action of N-arylpiperazines on 2-bromo-2-methyl- and 2-bromo-2-phenyl-1,3-indanediones derivatives of 2-(N-phenylpiperazinyl)-2-substituted-1,3-indanediones have been obtained, and these have been reduced with sodium borohydrite to the corresponding 1,3-indanediol derivatives. The 2-(arylpiperazinyl)-2-substituted-1,3-indanediones and the(More)
Demethylation of methindione was shown to take place in vivo in rats. The process involves the participation of the microsomal NADPH-dependent electron transport system. In experiments in vivo demethylation of methindione takes place rapidly and is accompanied by the partial loss of its anticonvulsant properties.
To a ce r t a in extent, the physiological act iv i ty of the amiaoindanediones is due to the favorable combination of an amino group and a P-d icarbonyl grouping. It could the re fo re be supposed that the p r e sen ce o f two such groupings in 2 , 2 ' d i a m i n o 2 , 2 ' (phenylene)bisindane1,3-dione molecules might have an effect on the neut ro t ropic(More)
Amino derivatives of indan-l,3-dione are of interest as physiologically active materials having strongly expressed effect on the central nervous system [1-3]. A purposeful search for psychopharmacological media in the aminomethylenindan-l,3-dione series is also very promising, since data are present that derivatives of aminomethylenindan-l-one have a strong(More)
2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxy-p hen yl)-1,4-dihydropyridine (ryodipine, PP-1466) causes lasting decrease in systolic and diastolic arterial pressure at intravenous and oral administration to anesthetized animals. In conscious rats with DOCA-salt (des-oxycortone) and spontaneous hypertension, as well as in rats with hypertension(More)