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Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal alpha-MSH instead gave a short-term(More)
Effects of a Hypericum extract in therapeutic use and hyperforin sodium salt were evaluated in rat and mouse avoidance tests. In a conditioned avoidance response (CAR) test on the rat, oral daily administration of hyperforin (1.25 mg/kg/day) or of the extract (50 mg/kg/day) before the training sessions considerably improved learning ability from the second(More)
Glutapyrone, a disodium salt of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido)- glutaric acid, is a representative of a novel 'class' of amino acid-containing 1,4-dihydropyridine (DHP) compounds developed at the Latvian Institute of Organic Synthesis, Riga, Latvia. Conceptually, the glutapyrone molecule can be regarded as a(More)
2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxy-p hen yl)-1,4-dihydropyridine (ryodipine, PP-1466) causes lasting decrease in systolic and diastolic arterial pressure at intravenous and oral administration to anesthetized animals. In conscious rats with DOCA-salt (des-oxycortone) and spontaneous hypertension, as well as in rats with hypertension(More)
Hydrazones of 5(6)-Benzimidazolylhydrazine (I-XIII). A solution of 2.22 g (0.01 mole) of 5(6)-hydraz inobenzimidazole dihydrochlor ide in 5-10 ml of wa te r is t r e a t ed with an equ imola r amount of the app rop r i ate carbonyl compound, and heated on a wa te r bath for 10-30 min, until the hydrazone , fo rma t ion react ion is comple te . As it is fo(More)
i. K~ S. Raevskii, Pharmacology of Neurolepties [in Russian], Moscow (1976). 2. S. Jerchan and F. H. Shaw, Nature, 186, 1072 (1960). 3. J. Mendelson, Med. J. Aust., 2, 906-907, 909 (1975). 4. L. Chenkman, RZh Farmakologiya, No. i0, 54, 176 (1968). 5. J. K. Patnaik and M. M. Vohra, J. Med. Chem., 9, 483 (1966). 6. A. S. Zaks, L. G. Zil'bermints, et al.,in:(More)
In searching for new psychotropic materials , at the Institute of Organic Chemistry of the Academy of Sciences of the Latvian SSR, derivatives of aminoindane-l,3-diol have been synthesized and studied experimentally, and this has resulted in the appearance of a quite new range of substances, which have a selective antispasmodic action. Of these, the one(More)
The alkylation of isoxazolid-3-one (I) has been reported previously [i, 2]. This proceeded with the formation of mixtures of derivatives of two of its tautomeric forms. ]'he pharmacological properties of these products have been described [3]. For the further study of the chemical properties of heterocycle I and with the aim of searching for drugs we have(More)
Ear l i e r we showedthat derivatives of N-(1-adamantyl)-l~-substituted piperazines exhibit a marked influence on the central nervous sytem. The majority of these derivatives exert a stimulating effect, while certain of them, on the other hand, exert a depressive effect. The aim of the present work was to determine ff introducing a methylene group between(More)
Amino derivatives of indan-l,3-dione are of interest as physiologically active materials having strongly expressed effect on the central nervous system [1-3]. A purposeful search for psychopharmacological media in the aminomethylenindan-l,3-dione series is also very promising, since data are present that derivatives of aminomethylenindan-l-one have a strong(More)