Sjoerd M. Euser

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OBJECTIVES To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN Two independent population-based cohort studies. SETTING The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study(More)
Uric acid is a risk factor of cardiovascular disease, as well as a major natural antioxidant, prohibiting the occurrence of cellular damage. The relation between uric acid and cognitive decline, in which both vascular mechanisms and oxidative stress are thought to play a role, is unknown. Therefore we assessed the relation between serum uric acid levels and(More)
Legionella bacteria are ubiquitous in natural matrices and man-made systems. However, it is not always clear if these reservoirs can act as source of infection resulting in cases of Legionnaires' disease. This review provides an overview of reservoirs of Legionella reported in the literature, other than drinking water distribution systems. Levels of(More)
Visiting wellness centres is considered safe and relaxing and might provide health benefits for visitors with certain cardiovascular, dermatological or respiratory diseases. On the other hand, wellness centres could pose health risks, especially with respect to Legionnaires’ disease. We investigated the role of wellness centres in the occurrence of(More)
Background/Objective The Pragati programme is an on-going empowerment programme for female sex workers (FSWs) working and living in Bangalore, India. Pragati aims to reduce transmission of HIV and sexually transmitted infections (STIs) among FSWs. This study describes the STI incidence rate, contact rate, and condom use during follow-up years. Design(More)
An accumulating body of evidence suggests the involvement of an evolutionary conserved insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) pathway in the regulation of the life and health span in nematodes, flies, rodents, and humans. We studied the association between insulin/IGF-1 signaling and cognitive function among 1015 participants, 85 years(More)
OBJECTIVE To investigate the relationship between fasting glucose levels, insulin resistance, and cognitive impairment in old age. Diabetes is associated with cognitive impairment in older people. However, the link between elevated fasting glucose levels and insulin resistance in nondiabetic individuals, and the risk of cognitive impairment is unclear. (More)
During August and September 2010 an unexpected high number of domestic cases of Legionnaires' disease (LD) were reported in The Netherlands. To examine this increase, patient characteristics and results of source finding and environmental sampling during the summer peak were compared to other domestic cases in 2008-2011. This analysis did not provide an(More)
AIMS For the majority of sporadic Legionnaires' disease cases the source of infection remains unknown. Infection may possible result from exposure to Legionella bacteria in sources that are not yet considered in outbreak investigations. Therefore, potential sources of pathogenic Legionella bacteria--natural soil and rainwater puddles on roads--were studied(More)
OBJECTIVES To determine the prospective relationship between blood pressure (BP) and cognitive function across a wide age range. DESIGN Prospective population-based cohort study. SETTING The Rotterdam Study and the Leiden 85-plus Study. PARTICIPANTS Three thousand seventy-eight men and women, initial age 55 to 84 from the Rotterdam Study and 276 men(More)