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Journals and Conferences
N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.
Petroleum installation employees have to balance safety goals versus other types of goals as a part of their daily work activities. To reduce the risk for incidents and accidents, it is critical to obtain a better understanding of how to facilitate adequate prioritization of safety goals, i.e., prioritizations in accordance with the standards set by the… (More)
Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.
All software systems can contain faults. In critical systems, this problem is alleviated by controlling the possible effects of a fault being executed, typically through techniques for achieving fault tolerance. Ensuring that failures are properly isolated, and not allowed to propagate, is essential when developing critical systems. In much of the research… (More)