Imatinib, the anti-Abl tyrosine kinase inhibitor used as first-line therapy in chronic myeloid leukemia (CML), eliminates CML cells mainly by apoptosis and induces autophagy. Analysis of imatinib-treated K562 cells reveals a cell population with cell cycle arrest, p27 increase and senescence-associated beta galactosidase (SA-β-Gal) staining. Preventing… (More)
crawled from YouTube using the keyword " economic collapse ". Using our open source and default parameter settings, a total of 35 partial near-duplicate (ND) segments are located, resulting in 10 visual clusters (or snippets). Figure 4 shows two examples of the snippets. Based on our experiments, the precision of ND localization is as high as 0.95 and the… (More)
Angiogenic factors are necessary for tumor proliferation and thus are attractive therapeutic targets. In this study, we have used engineered zinc finger protein (ZFP) transcription factors (TFs) to repress expression of vascular endothelial growth factor (VEGF)-A in human cancer cell lines. We create potent transcriptional repressors by fusing a designed… (More)
—This paper presents an improved method for microwave nondestructive dielectric measurement of layered media using a parallel-plate waveguide probe. The method bases on measuring the S parameter S 11 or reflection coefficient from the N-layer media over the range of 1 to 10 GHz. Formulation for the aperture admittance is presented which allows the solving… (More)
Here, we report the 4.1-Mb draft genome sequence of Bacillus subtilis subsp. natto strain CGMCC 2108, a high producer of poly-γ-glutamic acid (γ-PGA). This sequence will provide further help for the biosynthesis of γ-PGA and will greatly facilitate research efforts in metabolic engineering of B. subtilis subsp. natto strain CGMCC 2108.
We recently developed a longer lasting recombinant factor VIII-Fc fusion protein, rFVIIIFc, to extend the half-life of replacement FVIII for the treatment of people with hemophilia A. In order to elucidate the biological mechanism for the elongated half-life of rFVIIIFc at a cellular level we delineated the roles of VWF and the tissue-specific expression of… (More)