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BACKGROUND New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined with capecitabine in the patients with(More)
BACKGROUND No standard treatment for locally advanced pancreatic cancer (LAPC) is defined. PATIENTS AND METHODS Within a multi-centre, randomised phase II trial, 95 patients with LAPC were assigned to three different chemoradiotherapy (CRT) regimens: patients received conventionally fractionated radiotherapy of 50 Gy and were randomised to concurrent(More)
BACKGROUND We aimed to identify molecular epidermal growth factor receptor (EGFR) tissue biomarkers in pancreatic cancer (PC) patients treated with the anti-EGFR agent erlotinib within the phase 3 randomised AIO-PK0104 study. METHODS AIO-PK0104 was a multicenter trial comparing gemcitabine/erlotinib followed by capecitabine with capecitabine/erlotinib(More)
BACKGROUND To evaluate the efficacy and tolerability of the urokinase plasminogen activator (uPA) inhibitor upamostat in combination with gemcitabine in locally advanced pancreatic adenocarcinoma (LAPC). METHODS Within a prospective multicenter study, LAPC patients were randomly assigned to receive 1000 mg m(-2) of gemcitabine IV weekly either alone (arm(More)
BACKGROUND CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measurements of CYFRA 21-1, carbohydrate(More)
Sir, In a paper published on the October 1 issue, Frost (2013) analysed mortality from mesothelioma among members of the Great Britain Asbestos Survey (GBAS), to test whether higher asbestos exposure shortened mesothelioma latency. The author applied accelerated failure time models to estimate time ratios and concluded that there was not sufficient evidence(More)
Sir, We would like to thank Zanini et al (2010) for their critical discussion of our data from a randomised phase II trial in locally advanced pancreatic cancer (LAPC) that was recently published in this journal (Wilkowski et al, 2009). During the previous years, LAPC has been increasingly recognised as a separate disease entity in malignant pancreatic(More)
The electronic structure of the zincblende (ZB) phase of AlN, GaN and InN has been investigated by using the exact-exchange (EXX) Kohn–Sham density functional theory, with the Ga 3d and In 4d electrons treated both as valence states and as part of the frozen core. Our EXX bandgaps for AlN and GaN (obtained with the semicore Ga 3d electrons included as core(More)
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