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Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132(More)
PURPOSE To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions. MATERIALS AND METHODS Fifty-two female subjects (mean age = 58 years, age range = 25-75 years) with histopathologically proven breast lesions underwent DWI of the breasts with a single-shot echo-planar imaging (EPI) sequence(More)
In mammals, glucose-regulated gene expression has been best characterized in the liver, where increased glucose metabolism induces transcription of genes encoding enzymes involved in de novo lipogenesis. ChREBP and Mlx dimerize and function together as a glucose-responsive transcription factor to regulate target genes, such as liver-type pyruvate kinase,(More)
In the research field of image processing, mean squared error (MSE) and peak signal-to-noise ratio (PSNR) are extensively adopted as the objective visual quality metrics, mainly because of their simplicity for calculation and optimization. However, it has been well recognized that these pixel-based difference measures correlate poorly with the human(More)
In this paper, we propose to employ the convolutional neural network (CNN) for learning to answer questions from the image. Our proposed CNN provides an endto-end framework for learning not only the image representation, the composition model for question, but also the intermodal interaction between the image and question, for the generation of answer. More(More)
In this paper, we propose multimodal convolutional neural networks (m-CNNs) for matching image and sentence. Our m-CNN provides an end-to-end framework with convolutional architectures to exploit image representation, word composition, and the matching relations between the two modalities. More specifically, it consists of one image CNN encoding the image(More)
PURPOSE To study the features of proton magnetic resonance spectroscopy ((1)H-MRS) on amyotrophic lateral sclerosis (ALS) and its relation with clinical scale. MATERIALS AND METHODS Fifteen patients with definite or probable ALS and 15 age- and gender-matched normal controls were enrolled. (1)H-MRS was performed on a 3.0 Tesla GE imaging system (GE(More)
PURPOSE To retrospectively determine if in vivo magnetic resonance (MR) imaging can simultaneously depict differences between symptomatic and asymptomatic carotid atherosclerotic plaque. MATERIALS AND METHODS Institutional review board approval and informed consent were obtained for this HIPAA-compliant study. Twenty-three patients (21 men, two women;(More)
OBJECTIVES To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects. DESIGN We used functional magnetic resonance imaging (fMRI) to investigate the brain regions involved in electroacupuncture and manual acupuncture needle stimulation. A block design was adopted for the study. Each functional run(More)
The expression of genes encoding enzymes involved in de novo triglyceride synthesis (lipogenesis) is transcriptionally induced in the liver in response to increased glucose metabolism. The carbohydrate response element-binding protein (ChREBP) is a newly identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the(More)