Sivakumar Natarajan

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Nephronophthisis-related ciliopathies (NPHP-RC) are degenerative recessive diseases that affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia and centrosomes defined them as "ciliopathies." However, disease mechanisms remain poorly understood. Here, we identify by whole-exome resequencing, mutations of MRE11,(More)
A 14nm logic technology using 2 nd-generation FinFET transistors with a novel subfin doping technique, self-aligned double patterning (SADP) for critical patterning layers, and air-gapped interconnects at performance-critical layers is described. The transistors feature rectangular fins with 8nm fin width and 42nm fin height, 4 th generation high-k metal(More)
Chronic kidney disease (CKD) represents a major health burden. Its central feature of renal fibrosis is not well understood. By exome sequencing, we identified mutations in FAN1 as a cause of karyomegalic interstitial nephritis (KIN), a disorder that serves as a model for renal fibrosis. Renal histology in KIN is indistinguishable from that of(More)
In this paper, we present a new three layer OTC channel routing algorithm for high performance circuits. This router not only minimizes the channel height by using OTC areas but also minimizes the net lengths. Our algorithm is novel in two respects, one, we compute the track bound for each net and the other is that we use 45° segments for routing. We have(More)
Congenital abnormalities of the kidney and urinary tract (CAKUT) account for approximately half of children with chronic kidney disease and they are the most frequent cause of end-stage renal disease in children in the US. However, its genetic etiology remains mostly elusive. VACTERL association is a rare disorder that involves congenital abnormalities in(More)
A real time implementation of Fuzzy logic controller (FLC) for a spherical tank to control liquid level is studied. Control of liquid level in a spherical tank is highly non linear due to variation in the area of cross section of level system with change in shape .System identification of spherical tank system is done using black box model which is(More)
This paper presents the comparison of various Pulse Width Modulation (PWM) strategies for the three phase Diode Clamped Multi Level Inverter (DCMLI). The main contribution of this paper is the proposal of new modulation schemes with Variable Amplitude (VA) and various new schemes adopting the constant switching frequency and also variable switching(More)
This paper presents the comparison of Carrier Overlapping Pulse Width Modulation (COPWM) techniques for the Cascaded Multi Level Inverter (CMLI). A CMLI is controlled in this paper with Sinusoidal PWM (SPWM) reference, Third Harmonic Injection PWM (THI PWM) reference, Sixty degree PWM reference and Stepped wave reference with Carrier Overlapping (CO)(More)
This paper presents a novel approach for controlling the harmonics of output voltage of chosen Cascaded Multilevel Inverter (CMLI) employing trapezoidal PWM switching strategies. Carrier Disposition (CD) methods and Phase Shift (PS) method employed are evaluated using spectrum of the output voltage and other performance measures such as crest factor, form(More)
This paper presents a comprehensive analysis of various bipolar Multicarrier Pulse Width Modulation (MCPWM) strategies with various references for single phase Nine level Trinary Source cascaded inverter with Universal Motor load. This novel approach is for medium voltage applications. Performance factors such as %THD for Voltage and Current, VRMS, IRMS(More)