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Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site
Background: Reversible lysine acetylation regulates the fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD). Results: Residues Lys-318 and Lys-322 are responsible for these effects.Expand
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SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase
SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both targetExpand
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Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain
SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus. InExpand
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Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.
BACKGROUND The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands. These cells are rich inExpand
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Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma*♦
Hepatoblastoma (HB) is associated with aberrant activation of the β-catenin and Hippo/YAP signaling pathways. Overexpression of mutant β-catenin and YAP in mice induces HBs that express high levelsExpand
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The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide
Fatty acid oxidation (FAO)-driven H2O2 has been shown to be a major source of oxidative stress in several tissues and disease states. Here, we established that the mitochondrial flavoproteinExpand
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Effects of labor on placental fatty acid β oxidation
Objective: To measure the effect labor exerts on fatty acid (FA) oxidation in term human placentas, and to compare enzymes expression and activity between placenta and liver. Methods: PlacentalExpand
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Aspirin increases mitochondrial fatty acid oxidation.
The metabolic effects of salicylates are poorly understood. This study investigated the effects of aspirin on fatty acid oxidation. Aspirin increased mitochondrial long-chain fatty acid oxidation,Expand
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Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant*
Background: Mice with a defect in mitochondrial fatty acid oxidation (FAO) have reduced lung function but the mechanism is not known. Results: Acylcarnitines accumulate in FAO-deficient lungs andExpand
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Long-chain Acyl-CoA Dehydrogenase Deficiency as a Cause of Pulmonary Surfactant Dysfunction*
Background: The contribution of long-chain acyl-CoA dehydrogenase (LCAD) to human fatty acid oxidation is not understood. Results: LCAD localizes to lung alveolar type II cells, which produceExpand
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