Siva Sankar

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Lead is a known toxicant that has been implicated in encephalopathy in children and may affect the gastrointestinal and hematopoietic and other systems in adults. In fact, lead has been shown to compete with calcium for entry into the synaptosome and induce toxic effects. The aim of the current study was to evaluate the cytotoxic and genotoxic effects of(More)
California Bearing Ratio (CBR) value is an indicator of subgrade soil strength and is used often for design of flexible pavements. The conventional soaked CBR testing method is expensive and time consuming. To overcome this situation, it is appreciable to predict CBR value of subgrade soil with simple properties of soils such as index properties which(More)
A number of novel ofloxacin analogues were synthesized by modifying the carboxylic acid at C-6. To investigate the antimicrobial data on structural basis, in-silico docking studies of the tested compounds into the crystal structure of topoisomerase II using Autodock vina 4.0 program was performed in order to predict the affinity and orientation of the(More)
A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a-j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell(More)
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