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  • Siv Annegrethe Hjorth, Hans Thalsgaard Schambye, William J. Greenlee, Thue W Schwartz
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1994 (First Published: 9 December 1994)
  • To locate essential determinants for angiotensin II binding, we have performed a systematic mutational analysis of the exterior domain of the AT1 receptor. Receptor mutants, deficient in peptideContinue Reading
  • Søren M. Nielsen, Lindsey Nielsen, Siv Annegrethe Hjorth, Marilyn H. Perrin, Wylie W. Vale
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Published: 29 August 2000)
  • Constitutive activity, or ligand-independent activity, of mutant G protein-coupled receptors (GPCRs) has been described extensively and implicated in the pathology of many diseases. Using theContinue Reading
  • Kent Bondensgaard, Jens Breinholt, +6 authors Siv Annegrethe Hjorth
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 2007 (First Published: 10 August 2007)
  • The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21 structure is dominated by a well defined centralContinue Reading
  • Ole Jensen Hamming, Lishan Kang, +6 authors Rune Hartmann
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2012 (First Published: 16 March 2012)
  • IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R)Continue Reading
  • Hans Thalsgaard Schambye, Siv Annegrethe Hjorth, Derk J. Bergsma, Ganesh M. Sathe, Thue W Schwartz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1994 (First Published: 19 July 1994)
  • To characterize binding sites for nonpeptide angiotensin antagonists on the human angiotensin II receptor type 1 (AT1 receptor) we have systematically exchanged segments of the human receptor withContinue Reading
  • Solomon Perlman, Hans Thalsgaard Schambye, Ralph A. Rivero, William J. Greenlee, Siv Annegrethe Hjorth, Thue W Schwartz
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1995 (First Published: 27 January 1995)
  • Non-peptide ligands for peptide receptors for the G-protein-coupled type are generally antagonists, except in the opiate system. Recently, it was observed that a subset of biphenylimidazoleContinue Reading