Siu Shing Tong

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Effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) on the hepatic mixed-function oxidase system in male rats were studied both in vivo and in vitro. A single dose of CCNU (40 mg/kg) caused a significant reduction in hepatic mixed-function oxidase activities within 3 days after administration. The depression was prolonged for cytochrome P-450,(More)
Optimization is being increasing applied to engineering design problems throughout the world. iSIGHT is a generic engineering design environment that provides engineers with an optimization toolkit of leading optimization algorithms and an optimization advisor to solve their optimization needs. This paper focuses on the key role played by the toolkit’s(More)
Previous work revealed that portacaval anastomosis (PCA) in rats results in hepatic atrophy and marked decreases in components of the microsomal monooxygenase system such as cytochrome P-450. In the present study, the effects of PCA on hepatic monooxygenase activity were studied in more detail. We report that PCA, in general, produces effects resembling(More)
In vitro drug metabolism from liver and kidney of rats was studied for up to 12 days following a single intraperitoneal injection of the antineoplastic drug cisplatinum. At 3,5, and 8 days posttreatment, hepatic cytochrome P-450 dependent enzyme activity was increased 20-45%, but levels of cytochromes P-450 and b5 were unaltered. Hepatic in vitro stimulated(More)
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