Sita Kugel

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Chromatin and beyond: the multitasking roles for SIRT6.

Sita Kugel, Raúl Mostoslavsky
Trends in biochemical sciences
2014

In recent years there has been a large expansion in our understanding of SIRT6 biology including its structure, regulation, biochemical activity, and biological roles. SIRT6 functions as an… (More)

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Sita Kugel, Jessica L Feldman, +8 authors Raúl Mostoslavsky
Cell reports
2015

Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether… (More)

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

Sita Kugel, C Joseph Sebastian, +13 authors Raúl Mostoslavsky
Cell
2016

Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. Here, we uncover an epigenetic program mediated by the… (More)

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

J Etchegaray, Lukas Chavez, +15 authors Raúl Mostoslavsky
Nature Cell Biology
2015

How embryonic stem cells (ESCs) commit to specific cell lineages and yield all cell types of a fully formed organism remains a major question. ESC differentiation is accompanied by large-scale… (More)

SIRT1 Activators: The Evidence STACks up

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