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Staufen1-mediated mRNA decay functions in adipogenesis.
TLDR
Downregulation of SMD components attenuates adipogenesis in a way that is rescued by downregulation of an antiadipogenic factor, Krüppel-like factor 2 (KLF2), the mRNA of which is identified as a substrate of SMM, and a biological role for SMD in adipogenesis is identified. Expand
SMG5–PNRC2 is functionally dominant compared with SMG5–SMG7 in mammalian nonsense-mediated mRNA decay
TLDR
Results provide evidence that, to some extent, endogenous NMD substrates have their own binding preference for Upf1-interacting adaptors or effectors, and suggest the functional dominance of SMG 5-PNRC2, rather than SMG5-SMG7, under normal conditions. Expand
Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners
TLDR
The crystal structures of human ATG5 in complex with an N-terminal domain of ATG16L1 as well as an internal AIR domain of TECPR1 are described, providing new insights into the molecular details of the autophagosome maturation process, from its elongation to its fusion with a lysosome. Expand
bHLH transcription factors in neural development, disease, and reprogramming
TLDR
The powerful ability of bHLH factors to direct neuronal and glial cell fate specification and differentiation has been exploited in the relatively new field of cellular reprogramming, in which pluripotent stem cells or somatic stem cells are converted to neural lineages, often with a transcription factor-based lineage conversion strategy that includes one or more of the b HLH genes. Expand
A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis
TLDR
It is found that Neurog1 acts in an atypical fashion as it is required to suppress rather than promote neuronal differentiation in early corticogenesis, and employs different mechanisms to temper the pace of early neocortical neurogenesis. Expand
SMG 5 – PNRC 2 is functionally dominant compared with SMG 5 – SMG 7 in mammalian nonsense-mediated mRNA decay
In mammals, nonsense-mediated mRNA decay (NMD) functions in post-transcriptional gene regulation as well as mRNA surveillance. A key NMD factor, Upf1, becomes hyperphosphorylated by SMG1 kinaseExpand
Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding
TLDR
It is shown that Neurog2 and Ascl1 proneural genes regulate cortical progenitor cell differentiation through cross-repressive interactions to sustain neurogenic continuity in a lissencephalic rodent brain. Expand
Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex
TLDR
It is revealed that the proneural genes Neurog2 and Ascl1, which are together expressed in neocortical progenitors, cooperate to regulate the expression of components of the cortical derepression circuit to specify corticothalamic and subcerebral identities while repressing a callosal fate. Expand
SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay.
TLDR
Evidence is provided that downregulation of SMG1 causes the reduction in the level of Upf1 phosphorylation and delays adipogenesis, suggesting the functional involvement ofSMG1 in adipogenesis via SMD. Expand
Mechanisms of Cortical Differentiation.
TLDR
Current understanding of the intrinsic cues and environmental signals that govern cell fate specification and differentiation decisions during development of neuronal and glial lineages in the murine neocortex are reviewed. Expand
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