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A new conditional Egfr allele was used to dissect the roles of the receptor in eye development and to test two published models. EGFR function is necessary for morphogenetic furrow initiation, is not required for establishment of the founder R8 cell in each ommatidium, but is necessary to maintain its differentiated state. EGFR is required subsequently for(More)
—Software development in support of the tropospheric emission spectrometer instrument ground data system has undergone many challenges due to the uniqueness of the instrument, complexity of the science, data volume, and performance requirements. In this paper, we describe the software, its development, and the way in which many of these challenges were met.
Tetrazole and its derivatives are of great practical interest because Of their biological activity and are widely used in pharmaceutical preparations. The attention of research workers has been particularly drawn to 5aryltetrazolylalkanoic acids as potential antiinflammatory agents [1]. In the search for new biologically active compounds in the tetrazole(More)
Based on the mathematical (QSAR) predictions for 1-arylcycloalkyl-1-penicillins, we may expect that introduction of substituents such as F, Cl, and OH into the aromatic nucleus of these compounds may lead to derivatives possessing lower toxicity and higher acid resistance [1, 2]. Previously [3], we synthesized semisynthetic penicillins and cephalosporins(More)
The search for new $-lactam antibiotics directly entails investigation of the relationship between their structure and biological activity. Previously, we conducted a study on semisynthetic penicillins and cephalosporins of the cycloaliphatic series with alkoxyphenyl substituents [3, 4]. In order to predict the most effective preparations in this series,(More)
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