BACKGROUND Despite improved survival for the patients with diffuse large B-cell lymphoma (DLBCL), the prognosis after relapse is poor. The aim was to identify molecular events that contribute to relapse and treatment resistance in DLBCL. METHODS We analysed 51 prospectively collected pretreatment tumour samples from clinically high risk patients treated… (More)
Rituximab in combination with chemotherapy (immunochemotherapy) is one of the most effective treatments available for follicular lymphoma (FL). This study aimed to determine whether differences in gene expression in FL tissue correlate with outcome in response to rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy… (More)
OBJECTIVE To validate new mitochondrial myopathy serum biomarkers for diagnostic use. METHODS We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) mitochondrial diseases and (2) nonmitochondrial disorders partially overlapping with mitochondrial disorder phenotypes. We (3) did a meta-analysis of S-FGF21 in mitochondrial disease and (4)… (More)
9 REVIEW OF LITERATURE 10 1. Signal transduction 10 1.1. Signaling during cell growth, differentiation, and apoptosis 10 1.2. Transcritional regulation of gene expression 11 2. Mitogen activated protein kinases (MAPKs) 11 2.
Androgens control a variety of developmental processes that create the male phenotype and are important for maintaining male fertility and normal functions of tissues and organs that are not directly involved in procreation. Androgen receptor (AR) that mediates the biological actions of androgens is a member of the nuclear receptor superfamily of… (More)