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PURPOSE We sought to identify the genetic defect in a four-generation Chinese family with autosomal dominant congenital coralliform cataracts and demonstrate the functional analysis of a candidate gene in the family. METHODS Family history data were recorded. Clinical and ophthalmologic examinations were performed on affected and unaffected family(More)
PURPOSE To identify the genetic defect in a three-generation Chinese family with congenital cataracts. METHODS The phenotype of a three-generation Chinese family with congenital cataracts was recruited. Detailed family history and clinical data of the family were recorded. Candidate gene sequencing was performed to screen out the disease-causing mutation.(More)
Congenital cataract is a clinically and genetically heterogeneous group of eye disorders that causes visual impairment and childhood blindness. The purpose of this study was to identify the genetic defect associated with autosomal dominant congenital perinuclear cataract in a Chinese family. A detailed family history and clinical data of the family were(More)
The drawbacks of poloxamer hydrogel, such as dissolving quickly in aqueous solution, have limited its biomedical application. In order to improve the stability of hydrogel, a novel system was developed by combining the reversible thermo-sensitive property of poloxamer 407 and the thiol-ene reactivity between the acrylate and thiol groups. It was found that(More)
Acrylates have been used in ophthalmic practice as a paradigmatic implant material for decades, especially as intraocular lens for their excellent transparency. A novel polymeric shape memory system of chemically cross-linked acrylate-methacrylate copolymer networks was developed and characterized in this study. The thermomechanical properties, shape memory(More)
Objective. This is prospective randomized control trial to compare the mean keratometric corneal astigmatism diopter power (not surgical induced astigmatism) among preop and one-month and three-month postop phacoemulcification of either a clear temporal corneal incision or a superior scleral tunnel Incision, using only keratometric astigmatic power reading(More)
A G57W Mutation of CRYGS Associated with Autosomal Dominant Pulverulent Cataracts in a Chinese Family Zhenfei Yang, Qian Li, Siquan Zhu & Xu Ma To cite this article: Zhenfei Yang, Qian Li, Siquan Zhu & Xu Ma (2015) A G57W Mutation of CRYGS Associated with Autosomal Dominant Pulverulent Cataracts in a Chinese Family, Ophthalmic Genetics, 36:3, 281-283, DOI:(More)
The unique features of shape-memory polymers enables their use in minimally invasive surgical procedures with a compact starting material switching over to a voluminous structure in vivo. In this work, a series of transparent, thermoset (meth)acrylate shape-memory polymer networks with tailored thermomechanics have been synthesized and evaluated.(More)
  • Yang Zhao, Jiaxin Li, Ke Yang, Siquan Zhu
  • Journal of investigative surgery : the official…
  • 2017
PURPOSE To describe a manual prechop technique for splitting the nucleus of the lens using a recently developed reverse chopper. METHODS During the process, the reverse chopper and the Nagahara chopper are placed diagonally in the peripheral area of the nucleus of the lens after capsulorhexis. The reverse chopper and the Nagahara chopper then are pushed(More)
The reactive thermal-sensitive hydrogels, which combined the reversible thermosensitive and mild reactive property, were designed based on thiol-ene reaction in physiological conditions between thiol and acrylate capped thermosensitive Poloxamer 188. The modified P188A, P188SH, and their reactivity were characterized by (1)H NMR, FT-IR, GPC, DSC, Ellman(More)