Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines
- S. Anuchapreeda, Singkome Tima, C. Duangrat, P. Limtrakul
- BiologyCancer Chemotherapy and Pharmacology
- 1 September 2008
PureCurcumin, an excellent curcuminoid derivative, decreased WT1 gene expression in both transcriptional and translational levels and is one of a potential chemotherapeutic agent used for treatment of human leukemia.
Inhibitory effect of curcumin onMDR1 gene expression in patient leukemic cells
- S. Anuchapreeda, P. Thanarattanakorn, Somjai Sittipreechacharn, Singkome Tima, P. Chanarat, P. Limtrakul
- Biology, MedicineArchives of pharmacal research
- 2006
Curcumin treatment may provide a lead for clinical treatment of leukemia patients in the future after it was found that curcumin reduced MDR1 gene expression in the cells from 33 patients.
In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles against Candida albicans
- Anupon Iadnut, Ketsaya Mamoon, K. Tragoolpua
- BiologyEvidence-Based Complementary and Alternative…
- 30 November 2019
It is revealed that EEP-NPs mediates a potent anticandidal activity and key virulence factors by reducing the gene-encoding virulence-associated hyphal- adhesion proteins of C. albicans and, thereby, disrupting the morphologic presence and attenuating their virulence.
Cytotoxic effects of crude kaffir lime (Citrus hystrix, DC.) leaf fractional extracts on leukemic cell lines
- Fah Chueahongthong, C. Ampasavate, S. Okonogi, Singkome Tima, S. Anuchapreeda
- Chemistry
- 18 July 2011
Crude extracts from the leaves of kaffir lime (Citrus hystrix, DC.) were extracted using hexane, ethanol, ethyl acetate, butanol and methanol. The fractions were investigated in vitro for their…
EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES
- Rungkarn Sangkaruk, Methee Rungrojsakul, Singkome Tima, S. Anuchapreeda
- MedicineAfrican Journal of Traditional Complementary and…
- 13 January 2017
The hexane fraction from M. siamensis flowers inhibited cell proliferation via the suppression of WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 Cells.
Development of Microemulsion Containing Alpinia galanga Oil and Its Major Compounds: Enhancement of Antimicrobial Activities
- Nattakanwadee Khumpirapang, S. Klayraung, Singkome Tima, S. Okonogi
- MedicinePharmaceutics
- 1 February 2021
It is concluded that ME is a promising delivery system for AGO and its major compounds to enhance their water miscibility and antimicrobial activities.
Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
- Suwannee Sriyab, Nachtharinee Laosirisathian, W. Chaiyana
- MedicineScientific Reports
- 22 April 2021
The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients and was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural M MP-1 inhibitors.
Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation
- U. Fahmy, S. M. Badr-Eldin, N. Alhakamy
- BiologyPharmaceutics
- 27 May 2020
The optimized FLB niosomes integrated into gellan gum-based in situ gel exhibited enhanced ex vivo permeation and improved plasma and brain concentrations after nasal administration in rats compared to raw FLB.
Stable curcumin‐loaded polymeric micellar formulation for enhancing cellular uptake and cytotoxicity to FLT3 overexpressing EoL‐1 leukemic cells
- Singkome Tima, S. Anuchapreeda, C. Ampasavate, C. Berkland, S. Okonogi
- BiologyEuropean journal of pharmaceutics and…
- 1 May 2017
Anticancer activity of Zingiber ottensii essential oil and its nanoformulations
- Pawaret Panyajai, Fah Chueahongthong, S. Okonogi
- Chemistry, BiologyPLoS ONE
- 24 January 2022
Investigation using flow cytometry showed that ZOEO significantly increased the sub-G1 populations (cell death) in cell cycle analysis and induced cell apoptosis by apoptotic analysis and the developed nanoformulations significantly enhanced cytotoxicity of Z OEO, particularly against MCF-7.
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