Singkome Tima

Publications44
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Citations259
Highly Influential Citations4
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Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines
TLDR
PureCurcumin, an excellent curcuminoid derivative, decreased WT1 gene expression in both transcriptional and translational levels and is one of a potential chemotherapeutic agent used for treatment of human leukemia. Expand
Inhibitory effect of curcumin onMDR1 gene expression in patient leukemic cells
TLDR
Curcumin treatment may provide a lead for clinical treatment of leukemia patients in the future after it was found that curcumin reduced MDR1 gene expression in the cells from 33 patients. Expand
Cytotoxic effects of crude kaffir lime (Citrus hystrix, DC.) leaf fractional extracts on leukemic cell lines
Crude extracts from the leaves of kaffir lime (Citrus hystrix, DC.) were extracted using hexane, ethanol, ethyl acetate, butanol and methanol. The fractions were investigated in vitro for their… Expand
In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles against Candida albicans
TLDR
It is revealed that EEP-NPs mediates a potent anticandidal activity and key virulence factors by reducing the gene-encoding virulence-associated hyphal- adhesion proteins of C. albicans and, thereby, disrupting the morphologic presence and attenuating their virulence. Expand
Inhibitory effect of turmeric curcuminoids on FLT3 expression and cell cycle arrest in the FLT3-overexpressing EoL-1 leukemic cell line.
TLDR
This investigation has provided new findings regarding the effect of turmeric curcuminoids on FLT3 expression in leukemic cells. Expand
Stable curcumin‐loaded polymeric micellar formulation for enhancing cellular uptake and cytotoxicity to FLT3 overexpressing EoL‐1 leukemic cells
TLDR
The present study aims to develop a stable polymeric micellar formulation of curcumin (CM) with improved solubility and stability, and that is suitable for clinical applications in leukemia patients, and shows promising results for CM‐P407. Expand
Co-activation of WT1 and AP-1 proteins on WT1 gene promoter to induce WT1 gene expression in K562 cells.
TLDR
AP-1 contributes to the WT1 autoregulation of WT1 gene expression in leukaemic K562 cells in a dose-dependent manner as shown by immunoblotting. Expand
Dietary Turmeric Bisdemethoxycurcumin Suppresses Wilms’ Tumor 1 and CD34 Protein Expressions in KG-1a Leukemic Stem Cells
TLDR
Bisdemethoxycurcumin is a compound that calls for further studies of its process in the inhibition of WT1 and CD34 expressions in LSCs for the leukemia treatment. Expand
Development and Characterization of FLT3-Specific Curcumin-Loaded Polymeric Micelles as a Drug Delivery System for Treating FLT3-Overexpressing Leukemic Cells.
TLDR
The FLT-CM-micelles could enhance both solubility and cytotoxicity of CM on FLT3-overexpressing leukemic cells and may be used for enhancing antileukemic activity of CM and developed as a targeted drug delivery system in the future. Expand
EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES
TLDR
The hexane fraction from M. siamensis flowers inhibited cell proliferation via the suppression of WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 Cells. Expand
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