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Fourteen young male volunteers measured their habitual dietary intake for 2 weeks, then were told to increase their dietary sucrose while decreasing their other carbohydrates for 2 weeks and finally told to revert to their habitual diet while continuing to record their intake. Measurement of plasma constituents revealed a significant fall in HDL-cholesterol(More)
The study was undertaken to determine whether the phenomenon of endothelium-dependent relaxation was impaired in the spontaneously diabetic BB Wistar rat. Endothelium-dependent relaxation in the aorta of overtly diabetic animals was compared with that in nondiabetic BB rats. The relaxative responses were elicited in vitro to acetylcholine (-8.0 to -5.5 log(More)
Simulation is perhaps the most cost-effective tool to evaluate the operation of a system under design. A flexible, easy to extend, fully object-oriented, and multilayered simulator for interconnection networks can be a very useful tool for multicomputer designers and researchers. It is so desirable to attach newly designed components to the existing models(More)
This study has investigated the interactions between nitric oxide and haem protein radicals. The results demonstrate that nitric oxide interacts with activated ferryl myoglobin species with reduction to metmyoglobin, but the extent and duration of the reduction depends on the relative concentrations of nitric oxide and hydrogen peroxide. Ferryl myoglobin(More)
The necklace hypercube has recently been introduced as an attractive alternative to the well-known hypercube. Previous research on this network topology has mainly focused on topological properties, VLSI and algorithmic aspects of this network. Several analytical models have been proposed in the literature for different interconnection networks, as the most(More)
Low-density lipoproteins (LDL) are thought to influence directly the sensitivity of platelets, but this may only be the case when the LDL are modified by oxidation. In diabetes, LDL are known to be modified by non-enzymatic glycosylation, especially when the blood glucose concentrations are poorly controlled: platelet activation is also concomitantly(More)
In this paper, we present a dynamic load-balancing algorithm for optimistic gate level simulation making use of a machine learning approach. We first introduce two dynamic load-balancing algorithms oriented towards balancing the computational and communication load respectively in a Time Warp simulator. In addition, we utilize a multi-state Q-learning(More)
As a consequence of Moore’s law, the size of integrated circuits has grown extensively, resulting in simulation becoming the major bottleneck in the circuit design process. Consequently, parallel simulation has emerged as an approach which can be both fast and cost effective. In this paper, we examine the performance of a parallel Verilog simulator(More)
A major part of the design process for Integrated Circuits (IC) is the process of circuit verification, in which the correctness of a circuit's design is evaluated. Discrete event simulation is a central tool in this effort. As proscribed by Moore's law, the number of transistors which can be placed on an IC doubles every 18 months. As a result, simulation(More)
As proscribed by Moore's law, the size of integrated circuits has grown geometrically, resulting in simulation becoming the major bottleneck in the circuit design process. Parallel simulation provides us with a way to cope with this growth. In this paper, we describe an optimistic (time warp) parallel discrete event simulator which can simulate all(More)