Simone Schmid

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Protein kinase D (PKD) has been identified as a crucial regulator of secretory transport at the trans-Golgi network (TGN). Recruitment and activation of PKD at the TGN is mediated by the lipid diacylglycerol, a pool of which is generated by sphingomyelin synthase from ceramide and phosphatidylcholine. The nonvesicular transfer of ceramide from the(More)
1 Stand der Forschung Das Thema Wandlungsfähigkeit ist ein relativ junges Forschungsgebiet, das zu-nächst über den Betrachtungsbereich der Fabrikplanung in den Fokus von Indust-rie und Forschung gerückt ist. Wandlungsfähigkeit wird in der Fabrikplanung als neues Ziel angesehen. Unter verschiedenen Aspekten wurden Gestaltungsrichtlinien für modulare und(More)
AbstrAct The Knowledge Modeling and Description Language (KMDL ®) allows analysts to identify process patterns, which leads to improvements in knowledge-intensive processes. After modeling the business processes, knowledge and process potentials in daily business processes can be unleashed. The following contribution presents a specification of KMDL ® for(More)
The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission relies on the dimerization partner ErbB2, a receptor tyrosine kinase that is frequently overexpressed and/or amplified in breast cancer cells. Substantial(More)
In two experiments, we transferred perceptual load theory to the dynamic field of team sports and tested the predictions derived from the theory using a novel task and stimuli. We tested a group of college students (N = 33) and a group of expert team sport players (N = 32) on a general perceptual load task and a complex, soccer-specific perceptual load task(More)
Here we study the effects of inducible oncogenic K-Ras (G12V) expression on the polarized morphogenesis of colonic epithelial cells. We provide evidence that the autocrine production of heregulins, ligands for the ErbB3 receptor tyrosine kinase, is responsible for the hyperproliferation and aberrant 3D morphogenesis upon oncogenic K-Ras expression. This is(More)
The usefulness of robotic therapy devices in neurological rehabilitation therapy, especially in severely affected subacute stroke patients was proven by several clinical studies. Until now such devices are only available for inpatients receiving therapy inside rehab hospitals. A need for outpatient devices based on these proven concepts, which can be(More)