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The fate of all aerobic organisms is dependent on the varying intracellular concentrations of NADH and NADPH. The former is the primary ingredient that fuels ATP production via oxidative phosphorylation, while the latter helps maintain the reductive environment necessary for this process and other cellular activities. In this study we demonstrate a(More)
Although aluminum (Al), a known environmental toxin, has been implicated in a variety of neurological disorders, the molecular mechanism responsible for these conditions is not fully understood. In this report, we demonstrate the ability of Al to trigger mitochondrial dysfunction and ineffective adenosine triphosphate (ATP) production. This situation(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Abstract Aluminum (Al), a known environmental pollutant, has been linked to numerous(More)
Isocitrate lyase, ICL (EC 4.1.3.1), an enzyme that cleaves isocitrate into succinate, and glyoxylate appears to play a pivotal role in the detoxification of aluminum (Al) in Pseudomonas fluorescens. Here, we present evidence that the 4-fold increase in ICL activity observed in Al-stressed cells is due to the overexpression of this enzyme. Blue-Native-PAGE,(More)
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