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Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates
TLDR
Overall, the crude extracts of marine invertebrates herein investigated presented a high level of cytotoxic and antimycobacterial activities, a lower level of antibacterial activity and only a small number of crude extracts inhibited L-APRT.
A SARS-coronovirus 3CL protease inhibitor isolated from the marine sponge Axinella cf. corrugata: structure elucidation and synthesis
Two coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and esculetin-4-carboxylic acid ethyl ester (2), have been isolated from the marine sponge Axinella cf. corrugata. Structure
Isolantion and biological activities of secondary metabolites from the sponges monanchora aff. arbuscula, aplysina sp. petromica ciocalyptoides and topsentia ophiraphidies, from the ascidian didemnum
TLDR
The investigation of extracts from six species of marine invertebrates yielded one new and several known natural products, including the new N,N-dimethyl-O-methylethanolamine, which displayed cytotoxic activity against the cancer cell lines SF295, MDA-MB435, HCT8 and HL60.
The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose
A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
TLDR
The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins.
Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp. DLM33.
TLDR
The structure of the fungal metabolite roussoellatide has been established by spectroscopic and X-ray diffraction analyses and was consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides.
Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica.
TLDR
The results indicated that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites, and the new structures reported for 1-6 indicate that this strategy is a relevant Strategy.
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